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Confirmation of p-tau Ser356's association with Alzheimer's disease pathology and lowering in response to WZ4003 treatment in brain slice cultures. Reply to: "Phospho-tau Ser356 is mostly confined to pre-NFT neurons in Alzheimer's pathology".

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Title: Confirmation of p-tau Ser356's association with Alzheimer's disease pathology and lowering in response to WZ4003 treatment in brain slice cultures. Reply to: "Phospho-tau Ser356 is mostly confined to pre-NFT neurons in Alzheimer's pathology".
Authors: Taylor LW; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK., Simzer EM; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK., Young LFP; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK., Holt K; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK., Spires-Jones TL; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK., Durrant CS; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk.
Source: Acta neuropathologica [Acta Neuropathol] 2025 Dec 11; Vol. 150 (1), pp. 63. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Letter
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE; In Process
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  Data: Confirmation of p-tau Ser356's association with Alzheimer's disease pathology and lowering in response to WZ4003 treatment in brain slice cultures. Reply to: "Phospho-tau Ser356 is mostly confined to pre-NFT neurons in Alzheimer's pathology".
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  Data: <searchLink fieldCode="AU" term="%22Taylor+LW%22">Taylor LW</searchLink>; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Simzer+EM%22">Simzer EM</searchLink>; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Young+LFP%22">Young LFP</searchLink>; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Holt+K%22">Holt K</searchLink>; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Spires-Jones+TL%22">Spires-Jones TL</searchLink>; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Durrant+CS%22">Durrant CS</searchLink>; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%220412041%22">Acta neuropathologica</searchLink> [Acta Neuropathol] 2025 Dec 11; Vol. 150 (1), pp. 63. <i>Date of Electronic Publication: </i>2025 Dec 11.
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