View in EDS

The Histone Methyltransferase KMT2D Is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration-Resistant Prostate Cancer.

Saved in:
Bibliographic Details
Title: The Histone Methyltransferase KMT2D Is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration-Resistant Prostate Cancer.
Authors: Kittane S; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland.; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland., Ladewig E; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York., Li T; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland., Love JR; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, Switzerland., Blawski R; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland., Gao Y; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Arruabarrena-Aristorena A; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Bilbao, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain., Zhao P; Department of Oncology, KU Leuven, Leuven, Belgium., Dalrymple SL; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland., Liu H; AstraZeneca, Gaithersburg, Maryland., Guo X; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Sallaku M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Kelkar N; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland.; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland., Garcia-Martinez L; Sylvester Comprehensive Cancer Center, Miami, Florida., Carmona Sanz J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Chen W; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Stoudmann C; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, Switzerland., Baldino L; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Razavi-Mohseni M; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland., Kalemi I; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland., Beer MA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland., Castel P; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, New York., Brennen WN; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland., Scaltriti M; AstraZeneca, Gaithersburg, Maryland., Morey L; Sylvester Comprehensive Cancer Center, Miami, Florida., Cocco E; Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, Florida., Ji H; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Chan HM; AstraZeneca, Gaithersburg, Maryland., Battle A; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland., Leslie CS; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York., Karthaus WR; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, Switzerland., Toska E; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland.; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland.
Source: Cancer research [Cancer Res] 2026 Mar 02; Vol. 86 (5), pp. 1113-1131.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41379538
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: The Histone Methyltransferase KMT2D Is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration-Resistant Prostate Cancer.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Kittane+S%22">Kittane S</searchLink>; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland.; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Ladewig+E%22">Ladewig E</searchLink>; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Li+T%22">Li T</searchLink>; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Love+JR%22">Love JR</searchLink>; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Blawski+R%22">Blawski R</searchLink>; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Arruabarrena-Aristorena+A%22">Arruabarrena-Aristorena A</searchLink>; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Bilbao, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Zhao+P%22">Zhao P</searchLink>; Department of Oncology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Dalrymple+SL%22">Dalrymple SL</searchLink>; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; AstraZeneca, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Sallaku+M%22">Sallaku M</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Kelkar+N%22">Kelkar N</searchLink>; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland.; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Garcia-Martinez+L%22">Garcia-Martinez L</searchLink>; Sylvester Comprehensive Cancer Center, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Carmona+Sanz+J%22">Carmona Sanz J</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Stoudmann+C%22">Stoudmann C</searchLink>; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Baldino+L%22">Baldino L</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Razavi-Mohseni+M%22">Razavi-Mohseni M</searchLink>; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Kalemi+I%22">Kalemi I</searchLink>; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Beer+MA%22">Beer MA</searchLink>; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Castel+P%22">Castel P</searchLink>; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, New York.<br /><searchLink fieldCode="AU" term="%22Brennen+WN%22">Brennen WN</searchLink>; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Scaltriti+M%22">Scaltriti M</searchLink>; AstraZeneca, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Morey+L%22">Morey L</searchLink>; Sylvester Comprehensive Cancer Center, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Cocco+E%22">Cocco E</searchLink>; Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Ji+H%22">Ji H</searchLink>; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Chan+HM%22">Chan HM</searchLink>; AstraZeneca, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Battle+A%22">Battle A</searchLink>; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Leslie+CS%22">Leslie CS</searchLink>; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Karthaus+WR%22">Karthaus WR</searchLink>; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Toska+E%22">Toska E</searchLink>; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland.; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%222984705R%22">Cancer research</searchLink> [Cancer Res] 2026 Mar 02; Vol. 86 (5), pp. 1113-1131.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2984705R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-7445 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200085472%22">00085472 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41379538
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1158/0008-5472.CAN-25-2053
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1113
    Titles:
      – TitleFull: The Histone Methyltransferase KMT2D Is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration-Resistant Prostate Cancer.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Kittane S
      – PersonEntity:
          Name:
            NameFull: Ladewig E
      – PersonEntity:
          Name:
            NameFull: Li T
      – PersonEntity:
          Name:
            NameFull: Love JR
      – PersonEntity:
          Name:
            NameFull: Blawski R
      – PersonEntity:
          Name:
            NameFull: Gao Y
      – PersonEntity:
          Name:
            NameFull: Arruabarrena-Aristorena A
      – PersonEntity:
          Name:
            NameFull: Zhao P
      – PersonEntity:
          Name:
            NameFull: Dalrymple SL
      – PersonEntity:
          Name:
            NameFull: Liu H
      – PersonEntity:
          Name:
            NameFull: Guo X
      – PersonEntity:
          Name:
            NameFull: Sallaku M
      – PersonEntity:
          Name:
            NameFull: Kelkar N
      – PersonEntity:
          Name:
            NameFull: Garcia-Martinez L
      – PersonEntity:
          Name:
            NameFull: Carmona Sanz J
      – PersonEntity:
          Name:
            NameFull: Chen W
      – PersonEntity:
          Name:
            NameFull: Stoudmann C
      – PersonEntity:
          Name:
            NameFull: Baldino L
      – PersonEntity:
          Name:
            NameFull: Razavi-Mohseni M
      – PersonEntity:
          Name:
            NameFull: Kalemi I
      – PersonEntity:
          Name:
            NameFull: Beer MA
      – PersonEntity:
          Name:
            NameFull: Castel P
      – PersonEntity:
          Name:
            NameFull: Brennen WN
      – PersonEntity:
          Name:
            NameFull: Scaltriti M
      – PersonEntity:
          Name:
            NameFull: Morey L
      – PersonEntity:
          Name:
            NameFull: Cocco E
      – PersonEntity:
          Name:
            NameFull: Ji H
      – PersonEntity:
          Name:
            NameFull: Chan HM
      – PersonEntity:
          Name:
            NameFull: Battle A
      – PersonEntity:
          Name:
            NameFull: Leslie CS
      – PersonEntity:
          Name:
            NameFull: Karthaus WR
      – PersonEntity:
          Name:
            NameFull: Toska E
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 02
              M: 03
              Text: 2026 Mar 02
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1538-7445
          Numbering:
            – Type: volume
              Value: 86
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Cancer research
              Type: main
ResultId 1