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Artificial intelligence-driven metabolomics of retinal nerve fibre layer to profile risks of mortality and cardiometabolic diseases.

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Title: Artificial intelligence-driven metabolomics of retinal nerve fibre layer to profile risks of mortality and cardiometabolic diseases.
Authors: Yang S; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China., Xin Z; Department of Biomedical Engineering, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA., Li H; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China., Zhu Z; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China., Zhu LZ; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia., Shang X; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia., Huang W; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China., Zhang L; Clinical Medical Research Center, Children's Hospital of Nanjing Medical University, Nanjing, China.; Artificial Intelligence and Modelling in Epidemiology Program, Melbourne Sexual Health Centre, Alfred Health, Melbourne, Australia.; Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia., He M; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong Kong, China., Jonas JB; Rothschild Foundation Hospital, Institut Français de Myopie, Paris, France.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Congdon N; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China. ncongdon1@gmail.com.; Centre for Public Health, Queen's University Belfast, Belfast, UK. ncongdon1@gmail.com.; Orbis International, New York, NY, USA. ncongdon1@gmail.com., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. chingyu.cheng@nus.edu.sg.; Centre for Innovation and Precision Eye Health and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. chingyu.cheng@nus.edu.sg., Liang L; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China. lianglingyi@gzzoc.com., Wang W; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China. wangwei@gzzoc.com.; Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou, China. wangwei@gzzoc.com.; Guangdong Basic Research Center of Excellence for Major Blinding Eye Diseases Prevention and Treatment, Guangzhou, China. wangwei@gzzoc.com.; WHO Collaborating Centre for Eye Care and Vision, Guangzhou, China. wangwei@gzzoc.com.
Source: Nature communications [Nat Commun] 2025 Dec 11; Vol. 16 (1), pp. 11039. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xin+Z%22">Xin Z</searchLink>; Department of Biomedical Engineering, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhu+LZ%22">Zhu LZ</searchLink>; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Shang+X%22">Shang X</searchLink>; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Clinical Medical Research Center, Children's Hospital of Nanjing Medical University, Nanjing, China.; Artificial Intelligence and Modelling in Epidemiology Program, Melbourne Sexual Health Centre, Alfred Health, Melbourne, Australia.; Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22He+M%22">He M</searchLink>; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Jonas+JB%22">Jonas JB</searchLink>; Rothschild Foundation Hospital, Institut Français de Myopie, Paris, France.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Congdon+N%22">Congdon N</searchLink>; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China. ncongdon1@gmail.com.; Centre for Public Health, Queen's University Belfast, Belfast, UK. ncongdon1@gmail.com.; Orbis International, New York, NY, USA. ncongdon1@gmail.com.<br /><searchLink fieldCode="AU" term="%22Cheng+CY%22">Cheng CY</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. chingyu.cheng@nus.edu.sg.; Centre for Innovation and Precision Eye Health and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. chingyu.cheng@nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Liang+L%22">Liang L</searchLink>; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China. lianglingyi@gzzoc.com.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China. wangwei@gzzoc.com.; Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou, China. wangwei@gzzoc.com.; Guangdong Basic Research Center of Excellence for Major Blinding Eye Diseases Prevention and Treatment, Guangzhou, China. wangwei@gzzoc.com.; WHO Collaborating Centre for Eye Care and Vision, Guangzhou, China. wangwei@gzzoc.com.
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