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MMP-cleavable linker platform for tumour-responsive homo- and heterobivalent antibody-drug conjugates.

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Title: MMP-cleavable linker platform for tumour-responsive homo- and heterobivalent antibody-drug conjugates.
Authors: Counsell AJ; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk., Walsh SJ; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk.; Cancer Research UK Cambridge Institute Robinson Way Cambridge CB2 ORE UK., Ashman N; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk., Park M; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk., Dannheim FM; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk., King TA; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk., Wharton T; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk., Carroll JS; Cancer Research UK Cambridge Institute Robinson Way Cambridge CB2 ORE UK., Spring DR; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk.
Source: Chemical science [Chem Sci] 2025 Dec 03; Vol. 17 (5), pp. 2722-2731. Date of Electronic Publication: 2025 Dec 03 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: MMP-cleavable linker platform for tumour-responsive homo- and heterobivalent antibody-drug conjugates.
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  Data: <searchLink fieldCode="AU" term="%22Counsell+AJ%22">Counsell AJ</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Walsh+SJ%22">Walsh SJ</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk.; Cancer Research UK Cambridge Institute Robinson Way Cambridge CB2 ORE UK.<br /><searchLink fieldCode="AU" term="%22Ashman+N%22">Ashman N</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Park+M%22">Park M</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Dannheim+FM%22">Dannheim FM</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22King+TA%22">King TA</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Wharton+T%22">Wharton T</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Carroll+JS%22">Carroll JS</searchLink>; Cancer Research UK Cambridge Institute Robinson Way Cambridge CB2 ORE UK.<br /><searchLink fieldCode="AU" term="%22Spring+DR%22">Spring DR</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK spring@ch.cam.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101545951%22">Chemical science</searchLink> [Chem Sci] 2025 Dec 03; Vol. 17 (5), pp. 2722-2731. <i>Date of Electronic Publication: </i>2025 Dec 03 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Royal+Society+of+Chemistry%22">Royal Society of Chemistry </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101545951 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2041-6520 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220416520%22">20416520 </searchLink><i>NLM ISO Abbreviation: </i>Chem Sci <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1039/d5sc06664f
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              Text: 2025 Dec 03
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