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A generalizable cross-continent prediction of esophageal squamous cell carcinoma using the oral microbiome.

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Title: A generalizable cross-continent prediction of esophageal squamous cell carcinoma using the oral microbiome.
Authors: ElNaggar S; Program for Mathematical Genomics, Department of Systems Biology, Columbia University Irving Medical Center, New York, NY.; Department of Medicine, Columbia University Irving Medical Center, New York, NY., Chen WC; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; National Cancer Registry, a Division of the Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Network for Oncology Research in Africa (NORA), Global Health Working Group, Martin-Luther-University, Halle-Wittenberg, Germany.; South African Medical Research Council Common Epithelial Cancer Research Centre, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Prodehl LM; Surgical Gastroenterology Unit, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.; Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Marumo TK; Surgical Gastroenterology Unit, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.; Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Khan MU; Surgical Gastroenterology Unit, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.; Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Mathew CG; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Ruff P; South African Medical Research Council Common Epithelial Cancer Research Centre, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Division of Medical Oncology, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Jin Z; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY., Neugut AI; Department of Medicine, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY., Rustgi AK; Department of Medicine, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY., Uhlemann AC; Department of Medicine, Columbia University Irving Medical Center, New York, NY., Korem T; Program for Mathematical Genomics, Department of Systems Biology, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY., Abrams JA; Department of Medicine, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 24. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22ElNaggar+S%22">ElNaggar S</searchLink>; Program for Mathematical Genomics, Department of Systems Biology, Columbia University Irving Medical Center, New York, NY.; Department of Medicine, Columbia University Irving Medical Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Chen+WC%22">Chen WC</searchLink>; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; National Cancer Registry, a Division of the Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Network for Oncology Research in Africa (NORA), Global Health Working Group, Martin-Luther-University, Halle-Wittenberg, Germany.; South African Medical Research Council Common Epithelial Cancer Research Centre, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Prodehl+LM%22">Prodehl LM</searchLink>; Surgical Gastroenterology Unit, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.; Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Marumo+TK%22">Marumo TK</searchLink>; Surgical Gastroenterology Unit, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.; Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Khan+MU%22">Khan MU</searchLink>; Surgical Gastroenterology Unit, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.; Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Mathew+CG%22">Mathew CG</searchLink>; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Ruff+P%22">Ruff P</searchLink>; South African Medical Research Council Common Epithelial Cancer Research Centre, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Division of Medical Oncology, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Jin+Z%22">Jin Z</searchLink>; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY.<br /><searchLink fieldCode="AU" term="%22Neugut+AI%22">Neugut AI</searchLink>; Department of Medicine, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.<br /><searchLink fieldCode="AU" term="%22Rustgi+AK%22">Rustgi AK</searchLink>; Department of Medicine, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Uhlemann+AC%22">Uhlemann AC</searchLink>; Department of Medicine, Columbia University Irving Medical Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Korem+T%22">Korem T</searchLink>; Program for Mathematical Genomics, Department of Systems Biology, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Abrams+JA%22">Abrams JA</searchLink>; Department of Medicine, Columbia University Irving Medical Center, New York, NY.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
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              Text: 2025 Nov 24
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