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1-Year Outcomes of Novel Balloon-Expandable vs Contemporary Transcatheter Heart Valves in Severe Aortic Stenosis: The LANDMARK Trial.

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Title: 1-Year Outcomes of Novel Balloon-Expandable vs Contemporary Transcatheter Heart Valves in Severe Aortic Stenosis: The LANDMARK Trial.
Authors: Serruys PW; Department of Cardiology, School of Medicine, University of Galway, Galway, Ireland. Electronic address: patrick.w.j.c.serruys@gmail.com., Tobe A; Department of Cardiology, School of Medicine, University of Galway, Galway, Ireland., van Royen N; Department of Cardiology, Radboud University Hospital, Nijmegen, the Netherlands., Amat-Santos IJ; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain; Department of Cardiology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain., Hudec M; Department of Acute Cardiology, Middle-Slovak Institute of Cardiovascular Diseases, Banska Bystrica, Slovakia., Bunc M; Department of Cardiology, University Medical Centre Ljubljana, Ljubljana, Slovenia., Van den Branden BJL; Department of Cardiology, Amphia Hospital, Breda, the Netherlands., Laanmets P; Department of Invasive Cardiology, North Estonia Medical Centre, Tallinn, Estonia., Unic D; Department of Cardiac and Transplant Surgery, University Hospital Dubrava, Zagreb, Croatia., Merkely B; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Hermanides RS; Department of Cardiology, Isala Hospital, Zwolle, the Netherlands., Ninios V; Department of Cardiology, European Interbalkan Medical Center, Thessaloniki, Greece., Protasiewicz M; Department of Cardiology, Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland., Rensing BJWM; Department of Cardiology, St Antonius Hospital, Nieuwegein, the Netherlands., Martin PL; Department of Interventional Cardiology, University Hospital of Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain., Feres F; Department of Invasive Cardiology, Instituto Dante Pazzanese, São Paulo, Brazil., De Sousa Almeida M; CHRC, NOVA Medical School, NOVA University Lisbon, Lisbon, Portugal., van Belle E; Department of Interventional Cardiology, Lille University, Lille, France., Linke A; Department of Internal Medicine and Cardiology, University Clinic, Heart Center Dresden, University of Technology Dresden, Dresden, Germany., Ielasi A; Department of Interventional Cardiology, IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy., Montorfano M; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy; Interventional Cardiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Webster M; Department of Cardiology, Auckland City Hospital, Auckland, New Zealand., Toutouzas K; Department of Cardiology, Hippokration Hospital, Athens, Greece., Teiger E; Department of Interventional Cardiology, Henri Mondor University Hospital, Créteil, France., Bedogni F; Department of Clinical Cardiology, San Donato Hospital, Milan, Italy., Voskuil M; Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands., Pan M; Department of Cardiology, University Hospital Reina Sofía, University of Córdoba, IMIBIC, Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares, Córdoba, Spain., Angerås O; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden., Kim WK; Department of Cardiology and Angiology, University of Giessen and Marburg, Gießen, Germany; Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany., Rothe J; Department of Cardiology and Angiology, Campus Bad Krozingen, University Heart Center-University of Freiburg, Bad Krozingen, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany., Abdel-Wahab M; Department of Structural Heart Disease/Cardiology, Heart Center Leipzig at Leipzig University, Leipzig, Germany., Kristić I; Department of Cardiology, University Hospital of Split, Split, Croatia., Peral V; Department of Cardiology University Hospital Son Espases, Health Research Institute of the Balearic Islands, Palma de Mallorca, Spain., Garg S; Department of Cardiology, Royal Blackburn Hospital, Blackburn, United Kingdom; School of Medicine, University of Central Lancashire, Preston, United Kingdom., Tsai TY; Department of Cardiology, School of Medicine, University of Galway, Galway, Ireland., Thakkar A; Department of Clinical Research, Meril Life Sciences Pvt Ltd, Vapi, India., Chandra U; Department of Clinical Research, Meril Life Sciences Pvt Ltd, Vapi, India., Smits PC; Cardiovascular European Research Center, Massy, France., Morice MC; Cardiovascular European Research Center, Massy, France; Institut Cardiovasculaire Paris Sud, Hôpital Privé Jacques Cartier, Massy, France., Onuma Y; Department of Cardiology, School of Medicine, University of Galway, Galway, Ireland., Baumbach A; Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London and Barts Heart Centre, London, United Kingdom; Cleveland Clinic, London, United Kingdom.
Corporate Authors: LANDMARK Investigators
Source: Journal of the American College of Cardiology [J Am Coll Cardiol] 2026 Feb 03; Vol. 87 (4), pp. 362-381. Date of Electronic Publication: 2025 Nov 16.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Equivalence Trial; Comparative Study
Journal Info: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-3597 (Electronic) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: 1-Year Outcomes of Novel Balloon-Expandable vs Contemporary Transcatheter Heart Valves in Severe Aortic Stenosis: The LANDMARK Trial.
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  Data: <searchLink fieldCode="AU" term="%22Serruys+PW%22">Serruys PW</searchLink>; Department of Cardiology, School of Medicine, University of Galway, Galway, Ireland. Electronic address: patrick.w.j.c.serruys@gmail.com.<br /><searchLink fieldCode="AU" term="%22Tobe+A%22">Tobe A</searchLink>; Department of Cardiology, School of Medicine, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22van+Royen+N%22">van Royen N</searchLink>; Department of Cardiology, Radboud University Hospital, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Amat-Santos+IJ%22">Amat-Santos IJ</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain; Department of Cardiology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Hudec+M%22">Hudec M</searchLink>; Department of Acute Cardiology, Middle-Slovak Institute of Cardiovascular Diseases, Banska Bystrica, Slovakia.<br /><searchLink fieldCode="AU" term="%22Bunc+M%22">Bunc M</searchLink>; Department of Cardiology, University Medical Centre Ljubljana, Ljubljana, Slovenia.<br /><searchLink fieldCode="AU" term="%22Van+den+Branden+BJL%22">Van den Branden BJL</searchLink>; Department of Cardiology, Amphia Hospital, Breda, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Laanmets+P%22">Laanmets P</searchLink>; Department of Invasive Cardiology, North Estonia Medical Centre, Tallinn, Estonia.<br /><searchLink fieldCode="AU" term="%22Unic+D%22">Unic D</searchLink>; Department of Cardiac and Transplant Surgery, University Hospital Dubrava, Zagreb, Croatia.<br /><searchLink fieldCode="AU" term="%22Merkely+B%22">Merkely B</searchLink>; Heart and Vascular Center, Semmelweis University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Hermanides+RS%22">Hermanides RS</searchLink>; Department of Cardiology, Isala Hospital, Zwolle, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ninios+V%22">Ninios V</searchLink>; Department of Cardiology, European Interbalkan Medical Center, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Protasiewicz+M%22">Protasiewicz M</searchLink>; Department of Cardiology, Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Rensing+BJWM%22">Rensing BJWM</searchLink>; Department of Cardiology, St Antonius Hospital, Nieuwegein, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Martin+PL%22">Martin PL</searchLink>; Department of Interventional Cardiology, University Hospital of Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain.<br /><searchLink fieldCode="AU" term="%22Feres+F%22">Feres F</searchLink>; Department of Invasive Cardiology, Instituto Dante Pazzanese, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22De+Sousa+Almeida+M%22">De Sousa Almeida M</searchLink>; CHRC, NOVA Medical School, NOVA University Lisbon, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22van+Belle+E%22">van Belle E</searchLink>; Department of Interventional Cardiology, Lille University, Lille, France.<br /><searchLink fieldCode="AU" term="%22Linke+A%22">Linke A</searchLink>; Department of Internal Medicine and Cardiology, University Clinic, Heart Center Dresden, University of Technology Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Ielasi+A%22">Ielasi A</searchLink>; Department of Interventional Cardiology, IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Montorfano+M%22">Montorfano M</searchLink>; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy; Interventional Cardiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Webster+M%22">Webster M</searchLink>; Department of Cardiology, Auckland City Hospital, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Toutouzas+K%22">Toutouzas K</searchLink>; Department of Cardiology, Hippokration Hospital, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Teiger+E%22">Teiger E</searchLink>; Department of Interventional Cardiology, Henri Mondor University Hospital, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Bedogni+F%22">Bedogni F</searchLink>; Department of Clinical Cardiology, San Donato Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Voskuil+M%22">Voskuil M</searchLink>; Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Pan+M%22">Pan M</searchLink>; Department of Cardiology, University Hospital Reina Sofía, University of Córdoba, IMIBIC, Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares, Córdoba, Spain.<br /><searchLink fieldCode="AU" term="%22Angerås+O%22">Angerås O</searchLink>; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Kim+WK%22">Kim WK</searchLink>; Department of Cardiology and Angiology, University of Giessen and Marburg, Gießen, Germany; Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Rothe+J%22">Rothe J</searchLink>; Department of Cardiology and Angiology, Campus Bad Krozingen, University Heart Center-University of Freiburg, Bad Krozingen, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Abdel-Wahab+M%22">Abdel-Wahab M</searchLink>; Department of Structural Heart Disease/Cardiology, Heart Center Leipzig at Leipzig University, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Kristić+I%22">Kristić I</searchLink>; Department of Cardiology, University Hospital of Split, Split, Croatia.<br /><searchLink fieldCode="AU" term="%22Peral+V%22">Peral V</searchLink>; Department of Cardiology University Hospital Son Espases, Health Research Institute of the Balearic Islands, Palma de Mallorca, Spain.<br /><searchLink fieldCode="AU" term="%22Garg+S%22">Garg S</searchLink>; Department of Cardiology, Royal Blackburn Hospital, Blackburn, United Kingdom; School of Medicine, University of Central Lancashire, Preston, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tsai+TY%22">Tsai TY</searchLink>; Department of Cardiology, School of Medicine, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Thakkar+A%22">Thakkar A</searchLink>; Department of Clinical Research, Meril Life Sciences Pvt Ltd, Vapi, India.<br /><searchLink fieldCode="AU" term="%22Chandra+U%22">Chandra U</searchLink>; Department of Clinical Research, Meril Life Sciences Pvt Ltd, Vapi, India.<br /><searchLink fieldCode="AU" term="%22Smits+PC%22">Smits PC</searchLink>; Cardiovascular European Research Center, Massy, France.<br /><searchLink fieldCode="AU" term="%22Morice+MC%22">Morice MC</searchLink>; Cardiovascular European Research Center, Massy, France; Institut Cardiovasculaire Paris Sud, Hôpital Privé Jacques Cartier, Massy, France.<br /><searchLink fieldCode="AU" term="%22Onuma+Y%22">Onuma Y</searchLink>; Department of Cardiology, School of Medicine, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Baumbach+A%22">Baumbach A</searchLink>; Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London and Barts Heart Centre, London, United Kingdom; Cleveland Clinic, London, United Kingdom.
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