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Dinutuximab Beta Added to Temozolomide-Based Chemotherapy for Children With Relapsed and Refractory Neuroblastoma: Results of the ITCC-SIOPEN BEACON Immuno Phase II Trial.

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Title: Dinutuximab Beta Added to Temozolomide-Based Chemotherapy for Children With Relapsed and Refractory Neuroblastoma: Results of the ITCC-SIOPEN BEACON Immuno Phase II Trial.
Authors: Gray JC; Centre for Cancer Immunology, University of Southampton, Southampton, United Kingdom., Weston R; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham, Birmingham, United Kingdom., Owens C; Our Lady's Children's Hospital, Dublin, Republic of Ireland., Canete A; Unidad de Oncologia Pediatrica, Institute de Investigación Sanitaria La Fe, Valencia, Spain., Gambart M; Hôpital des Enfants, Toulouse, France., De Wilde B; Universitair Hospital Gent, Gent, Belgium., Nysom K; Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., van Eijkelenburg N; Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands.; Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands., Ladenstein R; Department of Studies and Statistics for Integrated Research and Projects, Department of Paediatrics, St Anna Children's Hospital and Children's Cancer Research Institute, Medical University of Vienna, Vienna, Austria., Castellano A; Bambino Gesù Children's Hospital, Rome, Italy., Gerber NU; Department of Oncology, University Children's Hospital, Zürich, Switzerland., Marshall LV; The Royal Marsden Hospital, Institute of Cancer Research, London, United Kingdom., Barone G; Great Ormond Street Hospital, London, United Kingdom., Rubio-San-Simon A; Hospital del Niño Jesus, Madrid, Spain., Ng A; Bristol Royal Hospital for Children, Bristol, United Kingdom., Vaidya S; The Royal Marsden Hospital, Institute of Cancer Research, London, United Kingdom., Gallego S; Hospital Vall d'Hebron, Barcelona, Spain., Makin G; Royal Manchester Children's Hospital, Manchester, United Kingdom., Burke GAA; Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom., McCarthy A; Royal Belfast Hospital for Sick Children, Belfast, United Kingdom., Murphy D; Al Jalila Children's Speciality Hospital, Dubai, United Arab Emirates., Zwaan CM; Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands.; Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands., López-Almaraz R; Hospital Universitario Cruces, Biobizkaia Health Research Institute, Barakaldo, Spain., Jannier S; Hôpital de Hautepierre, Strasbourg, France., Thebaud E; Department of Pediatric Oncology, Centre Hospitalier Universitaire, Nantes, France., Corradini N; Department of Pediatric Oncology, Pediatric Haematology and Oncology Institute, Léon Bérard Center, Lyon, France., Yeomanson D; Sheffield Children's Hospital, Sheffield, United Kingdom., Howell L; Alder Hey Children's Hospital, Liverpool, United Kingdom., Tweddle DA; Royal Victoria Infirmary Newcastle and Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Elliott M; Leeds General Infirmary, Leeds, United Kingdom., Hobin D; Birmingham Women and Children's Hospital, Birmingham, United Kingdom., Valteau-Couanet D; Gustave Roussy, Villejuif, France., Schleiermacher G; Institut Curie, Paris, France., Chastagner P; Hôpital d'Enfants, Nancy, France., Defachelles AS; Centre Oscar Lambret, Lille, France., Brichard B; Cliniques Universitaires Saint Luc, Brussels, Belgium., George S; The Royal Marsden Hospital, Institute of Cancer Research, London, United Kingdom., Chesler L; NIHR Birmingham Biomedical Research Centre, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom., Laidler J; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham, Birmingham, United Kingdom., Firth C; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham, Birmingham, United Kingdom., Holt G; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham, Birmingham, United Kingdom., Moroz V; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham, Birmingham, United Kingdom., Pearson ADJ; The Royal Marsden Hospital, Institute of Cancer Research, London, United Kingdom., Gates S; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham, Birmingham, United Kingdom., Wheatley K; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham, Birmingham, United Kingdom., Kearns P; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham, Birmingham, United Kingdom.; NIHR Birmingham Biomedical Research Centre, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom., Moreno L; Hospital Vall d'Hebron, Barcelona, Spain.
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2026 Jan 20; Vol. 44 (3), pp. 176-187. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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