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Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance.

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Title: Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance.
Authors: Duckett K; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK., McClellan A; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Corbin LJ; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Cimino I; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK., Elhakeem A; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Goncalves Soares A; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Williamson A; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK., Cross E; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK., Fairhurst-Hunter Z; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Petrovski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Rimmington D; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK., Alegre-Díaz J; Experimental Medicine Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico., Berumen J; Experimental Medicine Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico., Kuri-Morales P; Experimental Medicine Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico; Instituto Tecnológico y de Estudios Superiores de Monterrey, Tecnológico, Monterrey, Nuevo León, Mexico., Tapia-Conyer R; Experimental Medicine Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico., Mokrosinski J; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK., Farooqi IS; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Saleheen D; Center for Non-Communicable Diseases, Karachi, Pakistan; Columbia University Irving Medical Center, New York, NY, USA., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK., Timpson NJ; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Coll AP; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK., Raffan E; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. Electronic address: er311@cam.ac.uk., Lam BYH; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK. Electronic address: yhbl2@cam.ac.uk., O'Rahilly S; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK. Electronic address: so104@cam.ac.uk.
Corporate Authors: BELIEVE study
Source: Molecular metabolism [Mol Metab] 2026 Jan; Vol. 103, pp. 102301. Date of Electronic Publication: 2025 Dec 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Duckett+K%22">Duckett K</searchLink>; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22McClellan+A%22">McClellan A</searchLink>; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Corbin+LJ%22">Corbin LJ</searchLink>; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Cimino+I%22">Cimino I</searchLink>; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Elhakeem+A%22">Elhakeem A</searchLink>; 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Center for Non-Communicable Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Saleheen+D%22">Saleheen D</searchLink>; Center for Non-Communicable Diseases, Karachi, Pakistan; Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Butterworth+AS%22">Butterworth AS</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Timpson+NJ%22">Timpson NJ</searchLink>; 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Electronic address: er311@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Lam+BYH%22">Lam BYH</searchLink>; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK. Electronic address: yhbl2@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22O'Rahilly+S%22">O'Rahilly S</searchLink>; Medical Research Council Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK. Electronic address: so104@cam.ac.uk.
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