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Is there a role for anticoagulation with dabigatran in S. aureus bacteremia? Protocol for the adjunctive treatment domain of the Staphylococcus aureus Network Adaptive Platform (SNAP) randomised controlled trial.

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Title: Is there a role for anticoagulation with dabigatran in S. aureus bacteremia? Protocol for the adjunctive treatment domain of the Staphylococcus aureus Network Adaptive Platform (SNAP) randomised controlled trial.
Authors: McDonald EG; Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada emily.mcdonald@mcgill.ca., Cheng MP; McGill University, Montreal, Québec, Canada., Davis JS; The University of Newcastle School of Medicine and Public Health, Callaghan, New South Wales, Australia., Goodman AL; Centre for Clinical Infection and Diagnostics Research, Guy's and Saint Thomas' NHS Foundation Trust, London, UK.; King's College London Faculty of Life Sciences and Medicine, London, UK., Lawler PR; Department of Cardiology, McGill University Health Centre, Montreal, Québec, Canada., Marsh J; The University of Western Australia - Perth Campus, Perth, Western Australia, Australia., Mertz D; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Paul M; Technion Israel Institute of Technology, Haifa, Israel., Rodriguez-Baño J; Hospital Universitario Virgen Macarena, Seville, Spain., Siegal DM; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Tong SY; Department of Infectious Diseases, University of Melbourne, Melbourne, Victoria, Australia., Walls G; Middlemore Hosp, Middlemore, UK., Lee TC; McGill University Health Centre, Montreal, Québec, Canada.
Corporate Authors: SNAP Global Trial Steering Committee
Source: BMJ open [BMJ Open] 2025 Dec 12; Vol. 15 (12), pp. e107493. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22McDonald+EG%22">McDonald EG</searchLink>; Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada emily.mcdonald@mcgill.ca.<br /><searchLink fieldCode="AU" term="%22Cheng+MP%22">Cheng MP</searchLink>; McGill University, Montreal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Davis+JS%22">Davis JS</searchLink>; The University of Newcastle School of Medicine and Public Health, Callaghan, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Goodman+AL%22">Goodman AL</searchLink>; Centre for Clinical Infection and Diagnostics Research, Guy's and Saint Thomas' NHS Foundation Trust, London, UK.; King's College London Faculty of Life Sciences and Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Lawler+PR%22">Lawler PR</searchLink>; Department of Cardiology, McGill University Health Centre, Montreal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Marsh+J%22">Marsh J</searchLink>; The University of Western Australia - Perth Campus, Perth, Western Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Mertz+D%22">Mertz D</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Paul+M%22">Paul M</searchLink>; Technion Israel Institute of Technology, Haifa, Israel.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Baño+J%22">Rodriguez-Baño J</searchLink>; Hospital Universitario Virgen Macarena, Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Siegal+DM%22">Siegal DM</searchLink>; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tong+SY%22">Tong SY</searchLink>; Department of Infectious Diseases, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Walls+G%22">Walls G</searchLink>; Middlemore Hosp, Middlemore, UK.<br /><searchLink fieldCode="AU" term="%22Lee+TC%22">Lee TC</searchLink>; McGill University Health Centre, Montreal, Québec, Canada.
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  Data: <searchLink fieldCode="CA" term="%22SNAP+Global+Trial+Steering+Committee%22">SNAP Global Trial Steering Committee</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101552874%22">BMJ open</searchLink> [BMJ Open] 2025 Dec 12; Vol. 15 (12), pp. e107493. <i>Date of Electronic Publication: </i>2025 Dec 12.
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