A co-culture model of dopaminergic and glutamatergic neurons derived from patients with idiopathic schizophrenia reveals a hypodopaminergic phenotype.

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Title: A co-culture model of dopaminergic and glutamatergic neurons derived from patients with idiopathic schizophrenia reveals a hypodopaminergic phenotype.
Authors: Hartmann SM; Molecular Neurobiology, Department of Pharma and Biotech, NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany.; International Max Planck Research School, Graduate Training Centre of Neuroscience, University of Tübingen, 72076, Tübingen, Germany., Pizarro Garcia P; Molecular Neurobiology, Department of Pharma and Biotech, NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany., Heider J; Molecular Neurobiology, Department of Pharma and Biotech, NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany., Vogel S; Molecular Neurobiology, Department of Pharma and Biotech, NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany., Wüstner LS; Molecular Neurobiology, Department of Pharma and Biotech, NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany.; International Max Planck Research School, Graduate Training Centre of Neuroscience, University of Tübingen, 72076, Tübingen, Germany., Wüst R; Department of Psychiatry, Tübingen Center for Mental Health (TüCMH), University of Tübingen, 72076, Tübingen, Germany., Fallgatter AJ; Department of Psychiatry, Tübingen Center for Mental Health (TüCMH), University of Tübingen, 72076, Tübingen, Germany.; German Center for Mental Health (DZPG), partner site Tübingen, 72076, Tübingen, Germany., Volkmer H; Molecular Neurobiology, Department of Pharma and Biotech, NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany. hansjuergenvolkmer@gmail.com.; International Max Planck Research School, Graduate Training Centre of Neuroscience, University of Tübingen, 72076, Tübingen, Germany. hansjuergenvolkmer@gmail.com.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Apr; Vol. 31 (4), pp. 2376-2389. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1476-5578
DOI:10.1038/s41380-025-03384-4