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Multi-target design of fused cyclic pyrimidine-2-thione candidates as DNA intercalators and topoisomerase I/II inhibitors.

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Title: Multi-target design of fused cyclic pyrimidine-2-thione candidates as DNA intercalators and topoisomerase I/II inhibitors.
Authors: Khalil MS; Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt., Al-Karmalawy AA; Department of Pharmaceutical Chemistry, College of Pharmacy, The University of Mashreq, Baghdad, Iraq.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt., Abo Elmaaty A; Medicinal Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said, Egypt.; Medicinal Chemistry Department, Clinical Pharmacy Program, East Port Said National University, Port Said, Egypt., Elsayed GA; Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt., Hassan AMA; Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
Source: Future medicinal chemistry [Future Med Chem] 2026 Jan; Vol. 18 (1), pp. 35-48. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multi-target design of fused cyclic pyrimidine-2-thione candidates as DNA intercalators and topoisomerase I/II inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Khalil+MS%22">Khalil MS</searchLink>; Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Al-Karmalawy+AA%22">Al-Karmalawy AA</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, The University of Mashreq, Baghdad, Iraq.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.<br /><searchLink fieldCode="AU" term="%22Abo+Elmaaty+A%22">Abo Elmaaty A</searchLink>; Medicinal Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said, Egypt.; Medicinal Chemistry Department, Clinical Pharmacy Program, East Port Said National University, Port Said, Egypt.<br /><searchLink fieldCode="AU" term="%22Elsayed+GA%22">Elsayed GA</searchLink>; Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Hassan+AMA%22">Hassan AMA</searchLink>; Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
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  Data: <searchLink fieldCode="JN" term="%22101511162%22">Future medicinal chemistry</searchLink> [Future Med Chem] 2026 Jan; Vol. 18 (1), pp. 35-48. <i>Date of Electronic Publication: </i>2025 Dec 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101511162 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1756-8927 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217568919%22">17568919 </searchLink><i>NLM ISO Abbreviation: </i>Future Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1080/17568919.2025.2602424
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        Text: English
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              Text: 2026 Jan
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