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An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells.

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Title: An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells.
Authors: Anfuso B; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy., Velnati S; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy., Selvestrel D; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy., Garlant C; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste., Ferracci E; Laboratory of Stem Cells and Cancer Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy., Baj G; Department of Life Sciences, University of Trieste, Trieste, Italy., Parisse P; Elettra-Sincrotrone Trieste, Area Science Park Basovizza, 34149 Trieste, Italy; Institute of Materials (IOM), Italian National Research Council (CNR), Area Science Park Basovizza, 34149 Trieste, Italy., Overi D; Department of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Sapienza University of Rome, Roma, Italy., Bertolio R; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy., Bulla R; Department of Life Sciences, University of Trieste, Trieste, Italy., Sonzogni A; Department of Pathology, Policlinico di Monza, Monza, Italy., Bramuzzo M; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo,' Trieste, Italy., Casalis L; Elettra-Sincrotrone Trieste, Area Science Park Basovizza, 34149 Trieste, Italy., Cocomello N; Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy., Baratta F; Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy., Del Ben M; Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy., Giraudi P; Fondazione Italiana Fegato, Area Science Park Basovizza, Trieste, Italy., Tiribelli C; Fondazione Italiana Fegato, Area Science Park Basovizza, Trieste, Italy., Rosso N; Fondazione Italiana Fegato, Area Science Park Basovizza, Trieste, Italy., Mastronardi M; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste; Surgical Clinic Unit, Cattinara Hospital, ASUGI, Strada di Fiume, 447, 34149 Trieste, Italy., Tarchi P; Surgical Clinic Unit, Cattinara Hospital, ASUGI, Strada di Fiume, 447, 34149 Trieste, Italy., Pinamonti M; Department of Pathology, University Hospital Cattinara, Trieste, Italy., Zanconati F; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste., de Manzini N; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste; Surgical Clinic Unit, Cattinara Hospital, ASUGI, Strada di Fiume, 447, 34149 Trieste, Italy., Gaudio E; Department of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Sapienza University of Rome, Roma, Italy., Palmisano S; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste; Surgical Clinic Unit, Cattinara Hospital, ASUGI, Strada di Fiume, 447, 34149 Trieste, Italy., Bonazza D; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste., Del Sal G; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy; Department of Life Sciences, University of Trieste, Trieste, Italy; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy., Carpino G; Department of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Sapienza University of Rome, Roma, Italy., Chiacchiera F; Laboratory of Stem Cells and Cancer Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy., Sorrentino G; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste. Electronic address: giovanni.sorrentino@units.it.
Source: Cell reports [Cell Rep] 2025 Dec 23; Vol. 44 (12), pp. 116681. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells.
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  Data: <searchLink fieldCode="AU" term="%22Anfuso+B%22">Anfuso B</searchLink>; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Velnati+S%22">Velnati S</searchLink>; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Selvestrel+D%22">Selvestrel D</searchLink>; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Garlant+C%22">Garlant C</searchLink>; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste.<br /><searchLink fieldCode="AU" term="%22Ferracci+E%22">Ferracci E</searchLink>; Laboratory of Stem Cells and Cancer Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Baj+G%22">Baj G</searchLink>; Department of Life Sciences, University of Trieste, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Parisse+P%22">Parisse P</searchLink>; Elettra-Sincrotrone Trieste, Area Science Park Basovizza, 34149 Trieste, Italy; Institute of Materials (IOM), Italian National Research Council (CNR), Area Science Park Basovizza, 34149 Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Overi+D%22">Overi D</searchLink>; Department of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Sapienza University of Rome, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Bertolio+R%22">Bertolio R</searchLink>; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Bulla+R%22">Bulla R</searchLink>; Department of Life Sciences, University of Trieste, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Sonzogni+A%22">Sonzogni A</searchLink>; Department of Pathology, Policlinico di Monza, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Bramuzzo+M%22">Bramuzzo M</searchLink>; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo,' Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Casalis+L%22">Casalis L</searchLink>; Elettra-Sincrotrone Trieste, Area Science Park Basovizza, 34149 Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Cocomello+N%22">Cocomello N</searchLink>; Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Baratta+F%22">Baratta F</searchLink>; Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Del+Ben+M%22">Del Ben M</searchLink>; Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Giraudi+P%22">Giraudi P</searchLink>; Fondazione Italiana Fegato, Area Science Park Basovizza, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Tiribelli+C%22">Tiribelli C</searchLink>; Fondazione Italiana Fegato, Area Science Park Basovizza, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Rosso+N%22">Rosso N</searchLink>; Fondazione Italiana Fegato, Area Science Park Basovizza, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Mastronardi+M%22">Mastronardi M</searchLink>; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste; Surgical Clinic Unit, Cattinara Hospital, ASUGI, Strada di Fiume, 447, 34149 Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Tarchi+P%22">Tarchi P</searchLink>; Surgical Clinic Unit, Cattinara Hospital, ASUGI, Strada di Fiume, 447, 34149 Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Pinamonti+M%22">Pinamonti M</searchLink>; Department of Pathology, University Hospital Cattinara, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Zanconati+F%22">Zanconati F</searchLink>; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste.<br /><searchLink fieldCode="AU" term="%22de+Manzini+N%22">de Manzini N</searchLink>; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste; Surgical Clinic Unit, Cattinara Hospital, ASUGI, Strada di Fiume, 447, 34149 Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Gaudio+E%22">Gaudio E</searchLink>; Department of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Sapienza University of Rome, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Palmisano+S%22">Palmisano S</searchLink>; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste; Surgical Clinic Unit, Cattinara Hospital, ASUGI, Strada di Fiume, 447, 34149 Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Bonazza+D%22">Bonazza D</searchLink>; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste.<br /><searchLink fieldCode="AU" term="%22Del+Sal+G%22">Del Sal G</searchLink>; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy; Department of Life Sciences, University of Trieste, Trieste, Italy; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Carpino+G%22">Carpino G</searchLink>; Department of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Sapienza University of Rome, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Chiacchiera+F%22">Chiacchiera F</searchLink>; Laboratory of Stem Cells and Cancer Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Sorrentino+G%22">Sorrentino G</searchLink>; International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste. Electronic address: giovanni.sorrentino@units.it.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2025 Dec 23; Vol. 44 (12), pp. 116681. <i>Date of Electronic Publication: </i>2025 Dec 12.
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