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High-Penetrance Rare Variants Underlying Familial Lung Cancer Risk: Insights From Genetic Epidemiology of Lung Cancer Consortium.

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Title: High-Penetrance Rare Variants Underlying Familial Lung Cancer Risk: Insights From Genetic Epidemiology of Lung Cancer Consortium.
Authors: Liu Y; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas., Li Y; The University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico., Byun J; The University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico., Shaw VR; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas., Pikielny C; Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire., Peng B; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas., Cheng C; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas., Tsavachidis S; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas., Xiao X; The University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico., Zhu D; The University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico., Han Y; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas; The University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico., Gorlov IP; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas., Gorlova OY; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas., Cole M; Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire., Gaba CR; The University of Toledo College of Medicine, Toledo, Ohio., Crawford EL; The University of Toledo College of Medicine, Toledo, Ohio., Purrington K; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan., Goode EL; Mayo Clinic, Rochester, Minnesota., Yang P; Mayo Clinic, Scottsdale, Arizona., McKay J; International Agency for Research on Cancer, Lyon, France., Field JK; Roy Castle Lung Cancer Research Programme, The University of Liverpool, Department of Molecular and Clinical Cancer Medicine, Liverpool, United Kingdom., Liu G; Princess Margaret Cancer Center, Toronto, ON, Canada., Hung RJ; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Xia J; Institute of Biosciences and Technology, Texas A&M University, Houston, Texas., Choi J; Division of Cancer Epidemiology & Genetics at the National Cancer Institute, Bethesda, Maryland., Schabath MB; Departments of Cancer Epidemiology and Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida., LoPiccolo J; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Christiani DC; Harvard University T. H. Chan School of Public Health, and Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts., Bailey-Wilson J; National Human Genome Research Institute, Bethesda, Maryland., Schwartz AG; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan., Willey JC; The University of Toledo College of Medicine, Toledo, Ohio., Mandal D; Louisiana State University Health Sciences Center, New Orleans, Louisiana., Pinney SM; University of Cincinnati College of Medicine, Cincinnati, Ohio., Amos CI; The University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico. Electronic address: CIAmos@salud.unm.edu.
Source: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2026 May; Vol. 21 (5), pp. 103534. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101274235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-1380 (Electronic) Linking ISSN: 15560864 NLM ISO Abbreviation: J Thorac Oncol Subsets: MEDLINE
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  Data: High-Penetrance Rare Variants Underlying Familial Lung Cancer Risk: Insights From Genetic Epidemiology of Lung Cancer Consortium.
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  Data: <searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; The University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico.<br /><searchLink fieldCode="AU" term="%22Byun+J%22">Byun J</searchLink>; The University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico.<br /><searchLink fieldCode="AU" term="%22Shaw+VR%22">Shaw VR</searchLink>; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Pikielny+C%22">Pikielny C</searchLink>; Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire.<br /><searchLink fieldCode="AU" term="%22Peng+B%22">Peng B</searchLink>; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Cheng+C%22">Cheng C</searchLink>; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Tsavachidis+S%22">Tsavachidis S</searchLink>; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Xiao+X%22">Xiao X</searchLink>; The University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico.<br /><searchLink fieldCode="AU" term="%22Zhu+D%22">Zhu D</searchLink>; The University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico.<br /><searchLink fieldCode="AU" term="%22Han+Y%22">Han Y</searchLink>; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas; The University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico.<br /><searchLink fieldCode="AU" term="%22Gorlov+IP%22">Gorlov IP</searchLink>; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Gorlova+OY%22">Gorlova OY</searchLink>; Dan L. Duncan Comprehensive Cancer Center, Department of Medicine, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Cole+M%22">Cole M</searchLink>; Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire.<br /><searchLink fieldCode="AU" term="%22Gaba+CR%22">Gaba CR</searchLink>; The University of Toledo College of Medicine, Toledo, Ohio.<br /><searchLink fieldCode="AU" term="%22Crawford+EL%22">Crawford EL</searchLink>; The University of Toledo College of Medicine, Toledo, Ohio.<br /><searchLink fieldCode="AU" term="%22Purrington+K%22">Purrington K</searchLink>; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Goode+EL%22">Goode EL</searchLink>; Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Yang+P%22">Yang P</searchLink>; Mayo Clinic, Scottsdale, Arizona.<br /><searchLink fieldCode="AU" term="%22McKay+J%22">McKay J</searchLink>; International Agency for Research on Cancer, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Field+JK%22">Field JK</searchLink>; Roy Castle Lung Cancer Research Programme, The University of Liverpool, Department of Molecular and Clinical Cancer Medicine, Liverpool, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Liu+G%22">Liu G</searchLink>; Princess Margaret Cancer Center, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hung+RJ%22">Hung RJ</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Xia+J%22">Xia J</searchLink>; Institute of Biosciences and Technology, Texas A&M University, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Choi+J%22">Choi J</searchLink>; Division of Cancer Epidemiology & Genetics at the National Cancer Institute, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Schabath+MB%22">Schabath MB</searchLink>; Departments of Cancer Epidemiology and Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22LoPiccolo+J%22">LoPiccolo J</searchLink>; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Christiani+DC%22">Christiani DC</searchLink>; Harvard University T. H. Chan School of Public Health, and Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Bailey-Wilson+J%22">Bailey-Wilson J</searchLink>; National Human Genome Research Institute, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Schwartz+AG%22">Schwartz AG</searchLink>; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Willey+JC%22">Willey JC</searchLink>; The University of Toledo College of Medicine, Toledo, Ohio.<br /><searchLink fieldCode="AU" term="%22Mandal+D%22">Mandal D</searchLink>; Louisiana State University Health Sciences Center, New Orleans, Louisiana.<br /><searchLink fieldCode="AU" term="%22Pinney+SM%22">Pinney SM</searchLink>; University of Cincinnati College of Medicine, Cincinnati, Ohio.<br /><searchLink fieldCode="AU" term="%22Amos+CI%22">Amos CI</searchLink>; The University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico. Electronic address: CIAmos@salud.unm.edu.
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  Data: <searchLink fieldCode="JN" term="%22101274235%22">Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer</searchLink> [J Thorac Oncol] 2026 May; Vol. 21 (5), pp. 103534. <i>Date of Electronic Publication: </i>2025 Dec 11.
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