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Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation.

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Title: Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation.
Authors: Chen S; Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK., Lobato CB; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Section of Endocrinology, Department of Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark., Wong C; Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK., Manchanda Y; Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK., Viloria K; Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Davies I; Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK., Andersen DB; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ast J; Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK; Novo Nordisk Research Centre Oxford, Innovation Building, Oxford, UK., Sloop KW; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Hodson DJ; Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Broichhagen J; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany; Department of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg, Germany., Bloom S; Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK., Holst JJ; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Tan T; Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK., Tomas A; Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK. Electronic address: a.tomas-catala@imperial.ac.uk., Jones B; Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK. Electronic address: ben.jones@imperial.ac.uk.
Source: Molecular metabolism [Mol Metab] 2026 Jan; Vol. 103, pp. 102304. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE
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  Data: Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation.
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  Data: <searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Lobato+CB%22">Lobato CB</searchLink>; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Section of Endocrinology, Department of Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Wong+C%22">Wong C</searchLink>; Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Manchanda+Y%22">Manchanda Y</searchLink>; Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Viloria+K%22">Viloria K</searchLink>; Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Davies+I%22">Davies I</searchLink>; Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Andersen+DB%22">Andersen DB</searchLink>; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ast+J%22">Ast J</searchLink>; Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK; Novo Nordisk Research Centre Oxford, Innovation Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Sloop+KW%22">Sloop KW</searchLink>; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.<br /><searchLink fieldCode="AU" term="%22Hodson+DJ%22">Hodson DJ</searchLink>; Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Broichhagen+J%22">Broichhagen J</searchLink>; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany; Department of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bloom+S%22">Bloom S</searchLink>; Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Holst+JJ%22">Holst JJ</searchLink>; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Tan+T%22">Tan T</searchLink>; Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Tomas+A%22">Tomas A</searchLink>; Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK. Electronic address: a.tomas-catala@imperial.ac.uk.<br /><searchLink fieldCode="AU" term="%22Jones+B%22">Jones B</searchLink>; Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK. Electronic address: ben.jones@imperial.ac.uk.
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