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In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7.

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Title: In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7.
Authors: Scharf MM; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden., Kinsolving J; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden., Grätz L; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden.; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Bonn, Germany., Voss JH; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden., Carrasco-Busturia D; Division of Theoretical Chemistry and Biology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden., Forsberg B; Department of Physics, Chemistry and Biology, SciLifeLab, Linköping University, Linköping, Sweden., Kolb P; Philipps-Universität Marburg, Institute of Pharmaceutical Chemistry, Marburg, Germany., Schulte G; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden. gunnar.schulte@ki.se.
Source: Nature communications [Nat Commun] 2025 Dec 14; Vol. 16 (1), pp. 11138. Date of Electronic Publication: 2025 Dec 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Scharf+MM%22">Scharf MM</searchLink>; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Kinsolving+J%22">Kinsolving J</searchLink>; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Grätz+L%22">Grätz L</searchLink>; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden.; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Voss+JH%22">Voss JH</searchLink>; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Carrasco-Busturia+D%22">Carrasco-Busturia D</searchLink>; Division of Theoretical Chemistry and Biology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Forsberg+B%22">Forsberg B</searchLink>; Department of Physics, Chemistry and Biology, SciLifeLab, Linköping University, Linköping, Sweden.<br /><searchLink fieldCode="AU" term="%22Kolb+P%22">Kolb P</searchLink>; Philipps-Universität Marburg, Institute of Pharmaceutical Chemistry, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schulte+G%22">Schulte G</searchLink>; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden. gunnar.schulte@ki.se.
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              Text: 2025 Dec 14
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