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Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma.

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Title: Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma.
Authors: Joun GL; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Kempe EG; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Chen B; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Sterling JR; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Abbassi RH; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Friess D; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; The University of Queensland, Brisbane, QLD, Australia., Singleton M; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Choudhury C; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; The University of Queensland, Brisbane, QLD, Australia., Marian OC; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., du Preez WD; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Recasens A; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Clark T; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia., Du TY; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia., Low JKK; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia., Kim H; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Sydney, NSW, Australia., Yang P; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Sydney, NSW, Australia., Khor J; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Hoque M; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Indurthi DC; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Kuchibhotla M; Centre for Child Health Research, Medical School, University of Western Australia, Crawley, WA, Australia.; Cancer Centre, Telethon Kids Institute, Nedlands, WA, Australia., Palanisamy R; Centre for Child Health Research, Medical School, University of Western Australia, Crawley, WA, Australia.; Cancer Centre, Telethon Kids Institute, Nedlands, WA, Australia., Jorgensen WT; School of Chemistry, Faculty of Science, The University of Sydney, Sydney, NSW, Australia., Montgomery AP; School of Chemistry, Faculty of Science, The University of Sydney, Sydney, NSW, Australia., Baker JR; School of Science, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia., Higginbottom SL; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong, Fairy Meadow, NSW, Australia., Tomaskovic-Crook E; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong, Fairy Meadow, NSW, Australia., Crook JM; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Arto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong, Fairy Meadow, NSW, Australia., Loo L; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia., Day BW; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Neely GG; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia., Guccione E; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Therapeutics Discovery, Department of Oncological Sciences and Pharmacological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Bioinformatics for Next Generation Sequencing (BiNGS) Shared Resource Facility, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Johns TG; Centre for Child Health Research, Medical School, University of Western Australia, Crawley, WA, Australia.; Cancer Centre, Telethon Kids Institute, Nedlands, WA, Australia., Kassiou M; School of Chemistry, Faculty of Science, The University of Sydney, Sydney, NSW, Australia., Feng Y; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Harris L; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; The University of Queensland, Brisbane, QLD, Australia.; Queensland University of Technology, Brisbane, QLD, Australia., Don AS; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Munoz L; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. lenka.munoz@sydney.edu.au.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia. lenka.munoz@sydney.edu.au.
Source: Nature communications [Nat Commun] 2025 Dec 15; Vol. 16 (1), pp. 10905. Date of Electronic Publication: 2025 Dec 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma.
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