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Benchmarking progression-free survival ratio as primary endpoint in precision oncology clinical trials.

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Title: Benchmarking progression-free survival ratio as primary endpoint in precision oncology clinical trials.
Authors: Nichetti F; Oncology Unit 1, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. federico.nichetti@iov.veneto.it.; Computational Oncology, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany. federico.nichetti@iov.veneto.it., Hüllein J; Computational Oncology, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany., du Rusquec P; Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France.; INSERM U900 Research unit, Institut Curie, Saint-Cloud, France., Pleasance E; Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada., Chen L; Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Mock A; Institute of Pathology, University of Munich (LMU), Munich, Germany., Horak P; German Cancer Consortium (DKTK), Heidelberg, Germany.; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany., Ambrosini P; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Rota S; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Niger M; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Agnelli L; Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Tinè G; Biostatistics for Clinical Research Unit, Epidemiology and Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy., Edelmann D; Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; NCT Trial Center, National Center for Tumor Diseases, Heidelberg, Germany., Le Tourneau C; Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France.; INSERM U900 Research unit, Institut Curie, Saint-Cloud, France.; Paris-Saclay University, Paris, France., Laskin J; Department of Medical Oncology, BC Cancer, Vancouver, BC, Canada., Pruneri G; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Wang C; Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Hübschmann D; Computational Oncology, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Pattern Recognition and Digital Medicine Group, Heidelberg Institute for Stem cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany., de Braud F; Oncology Unit 1, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Fröhling S; German Cancer Consortium (DKTK), Heidelberg, Germany.; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany., Mariani L; Biostatistics for Clinical Research Unit, Epidemiology and Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.
Source: NPJ precision oncology [NPJ Precis Oncol] 2025 Dec 15; Vol. 10 (1), pp. 38. Date of Electronic Publication: 2025 Dec 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Benchmarking progression-free survival ratio as primary endpoint in precision oncology clinical trials.
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  Data: <searchLink fieldCode="AU" term="%22Nichetti+F%22">Nichetti F</searchLink>; Oncology Unit 1, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. federico.nichetti@iov.veneto.it.; Computational Oncology, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany. federico.nichetti@iov.veneto.it.<br /><searchLink fieldCode="AU" term="%22Hüllein+J%22">Hüllein J</searchLink>; Computational Oncology, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22du+Rusquec+P%22">du Rusquec P</searchLink>; Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France.; INSERM U900 Research unit, Institut Curie, Saint-Cloud, France.<br /><searchLink fieldCode="AU" term="%22Pleasance+E%22">Pleasance E</searchLink>; Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Mock+A%22">Mock A</searchLink>; Institute of Pathology, University of Munich (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Horak+P%22">Horak P</searchLink>; German Cancer Consortium (DKTK), Heidelberg, Germany.; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ambrosini+P%22">Ambrosini P</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rota+S%22">Rota S</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Niger+M%22">Niger M</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Agnelli+L%22">Agnelli L</searchLink>; Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tinè+G%22">Tinè G</searchLink>; Biostatistics for Clinical Research Unit, Epidemiology and Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Edelmann+D%22">Edelmann D</searchLink>; Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; NCT Trial Center, National Center for Tumor Diseases, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Le+Tourneau+C%22">Le Tourneau C</searchLink>; Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France.; INSERM U900 Research unit, Institut Curie, Saint-Cloud, France.; Paris-Saclay University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Laskin+J%22">Laskin J</searchLink>; Department of Medical Oncology, BC Cancer, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Pruneri+G%22">Pruneri G</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Hübschmann+D%22">Hübschmann D</searchLink>; Computational Oncology, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Pattern Recognition and Digital Medicine Group, Heidelberg Institute for Stem cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22de+Braud+F%22">de Braud F</searchLink>; Oncology Unit 1, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fröhling+S%22">Fröhling S</searchLink>; German Cancer Consortium (DKTK), Heidelberg, Germany.; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mariani+L%22">Mariani L</searchLink>; Biostatistics for Clinical Research Unit, Epidemiology and Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101708166%22">NPJ precision oncology</searchLink> [NPJ Precis Oncol] 2025 Dec 15; Vol. 10 (1), pp. 38. <i>Date of Electronic Publication: </i>2025 Dec 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101708166 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2397-768X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222397768X%22">2397768X </searchLink><i>NLM ISO Abbreviation: </i>NPJ Precis Oncol <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2025 Dec 15
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