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Diabetogenic processes for insulin resistance-linked hyperinsulinaemia are associated with colorectal cancer.

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Title: Diabetogenic processes for insulin resistance-linked hyperinsulinaemia are associated with colorectal cancer.
Authors: Zhou X; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Sevilla-Gonzalez M; Clinical and Translational Epidemiological Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Phipps AI; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Udler M; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Castellví-Bel S; Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain., Chan AT; Clinical and Translational Epidemiological Unit, Massachusetts General Hospital, Boston, MA, USA.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Pellatt AJ; Intermountain Health, Salt Lake City, UT, USA., Schoen RE; Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Giovannucci E; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Gunter MJ; Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.; Department of Epidemiology and Biostatistics School of Public Health, Imperial College London, London, UK., Florez JC; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Song M; Clinical and Translational Epidemiological Unit, Massachusetts General Hospital, Boston, MA, USA.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Merino J; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. jordi.merino@sund.ku.dk.; Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA. jordi.merino@sund.ku.dk.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. jordi.merino@sund.ku.dk.
Source: Diabetologia [Diabetologia] 2026 Apr; Vol. 69 (4), pp. 942-952. Date of Electronic Publication: 2025 Dec 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
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  Data: Diabetogenic processes for insulin resistance-linked hyperinsulinaemia are associated with colorectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sevilla-Gonzalez+M%22">Sevilla-Gonzalez M</searchLink>; Clinical and Translational Epidemiological Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Phipps+AI%22">Phipps AI</searchLink>; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Udler+M%22">Udler M</searchLink>; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Castellví-Bel+S%22">Castellví-Bel S</searchLink>; Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Chan+AT%22">Chan AT</searchLink>; Clinical and Translational Epidemiological Unit, Massachusetts General Hospital, Boston, MA, USA.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pellatt+AJ%22">Pellatt AJ</searchLink>; Intermountain Health, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Schoen+RE%22">Schoen RE</searchLink>; Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Giovannucci+E%22">Giovannucci E</searchLink>; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gunter+MJ%22">Gunter MJ</searchLink>; Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.; Department of Epidemiology and Biostatistics School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Florez+JC%22">Florez JC</searchLink>; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Peters+U%22">Peters U</searchLink>; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Song+M%22">Song M</searchLink>; Clinical and Translational Epidemiological Unit, Massachusetts General Hospital, Boston, MA, USA.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Merino+J%22">Merino J</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. jordi.merino@sund.ku.dk.; Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA. jordi.merino@sund.ku.dk.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. jordi.merino@sund.ku.dk.
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