TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability.
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| Title: | TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability. |
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| Authors: | Moffatt C; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Arora A; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Vaeth KF; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Guzman BB; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bhardwaj G; Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA., Hoelscher A; RNA Bioscience Initiative, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Gifford LB; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Russ HA; Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA., Dominguez D; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. didoming@email.unc.edu.; RNA Discovery Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. didoming@email.unc.edu., Taliaferro JM; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. matthew.taliaferro@cuanschutz.edu.; RNA Bioscience Initiative, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. matthew.taliaferro@cuanschutz.edu. |
| Source: | The EMBO journal [EMBO J] 2026 Feb; Vol. 45 (3), pp. 692-721. Date of Electronic Publication: 2025 Dec 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-025-00653-4 |
