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TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability.

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Title: TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability.
Authors: Moffatt C; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Arora A; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Vaeth KF; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Guzman BB; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bhardwaj G; Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA., Hoelscher A; RNA Bioscience Initiative, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Gifford LB; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Russ HA; Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA., Dominguez D; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. didoming@email.unc.edu.; RNA Discovery Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. didoming@email.unc.edu., Taliaferro JM; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. matthew.taliaferro@cuanschutz.edu.; RNA Bioscience Initiative, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. matthew.taliaferro@cuanschutz.edu.
Source: The EMBO journal [EMBO J] 2026 Feb; Vol. 45 (3), pp. 692-721. Date of Electronic Publication: 2025 Dec 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability.
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  Data: <searchLink fieldCode="AU" term="%22Moffatt+C%22">Moffatt C</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Arora+A%22">Arora A</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Vaeth+KF%22">Vaeth KF</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Guzman+BB%22">Guzman BB</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Bhardwaj+G%22">Bhardwaj G</searchLink>; Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Hoelscher+A%22">Hoelscher A</searchLink>; RNA Bioscience Initiative, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Gifford+LB%22">Gifford LB</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Russ+HA%22">Russ HA</searchLink>; Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Dominguez+D%22">Dominguez D</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. didoming@email.unc.edu.; RNA Discovery Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. didoming@email.unc.edu.<br /><searchLink fieldCode="AU" term="%22Taliaferro+JM%22">Taliaferro JM</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. matthew.taliaferro@cuanschutz.edu.; RNA Bioscience Initiative, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. matthew.taliaferro@cuanschutz.edu.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 Feb; Vol. 45 (3), pp. 692-721. <i>Date of Electronic Publication: </i>2025 Dec 15.
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              Text: 2026 Feb
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