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Demonstration of in vivo efficacy, cryo-EM-epitope identification, and breadth of two anti-alphavirus bispecific single domain antibodies.

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Title: Demonstration of in vivo efficacy, cryo-EM-epitope identification, and breadth of two anti-alphavirus bispecific single domain antibodies.
Authors: Gardner CL; Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, Maryland, USA., Pletnev S; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Liu JL; Center for Biomolecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA., Anderson GP; Center for Biomolecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA., Shriver-Lake LC; Center for Biomolecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA., Bylund T; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Green C; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Stephens T; Vaccine Research Center Electron Microscopy Unit, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA., Sutton MS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Tsybovsky Y; Vaccine Research Center Electron Microscopy Unit, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA., Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, and Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA., Zhou T; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Goldman ER; Center for Biomolecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA., Burke CW; Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, Maryland, USA.
Source: Journal of virology [J Virol] 2026 Jan 20; Vol. 100 (1), pp. e0187525. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Journal Article; Research Support, N.I.H., Intramural
Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Demonstration of in vivo efficacy, cryo-EM-epitope identification, and breadth of two anti-alphavirus bispecific single domain antibodies.
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  Data: <searchLink fieldCode="AU" term="%22Gardner+CL%22">Gardner CL</searchLink>; Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Pletnev+S%22">Pletnev S</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Liu+JL%22">Liu JL</searchLink>; Center for Biomolecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+GP%22">Anderson GP</searchLink>; Center for Biomolecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Shriver-Lake+LC%22">Shriver-Lake LC</searchLink>; Center for Biomolecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Bylund+T%22">Bylund T</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Green+C%22">Green C</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Stephens+T%22">Stephens T</searchLink>; Vaccine Research Center Electron Microscopy Unit, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Sutton+MS%22">Sutton MS</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Tsybovsky+Y%22">Tsybovsky Y</searchLink>; Vaccine Research Center Electron Microscopy Unit, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Roederer+M%22">Roederer M</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Kwong+PD%22">Kwong PD</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, and Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+T%22">Zhou T</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Goldman+ER%22">Goldman ER</searchLink>; Center for Biomolecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Burke+CW%22">Burke CW</searchLink>; Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, Maryland, USA.
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