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An alveolar macrophage-targeted ciprofloxacin polymeric prodrug improves survival in a murine model of Klebsiella pneumoniae pneumonia.

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Title: An alveolar macrophage-targeted ciprofloxacin polymeric prodrug improves survival in a murine model of Klebsiella pneumoniae pneumonia.
Authors: López CL; Department of Bioengineering, University of Washington, Seattle, Washington, USA., Rerolle G; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA., Snyder S; Department of Bioengineering, University of Washington, Seattle, Washington, USA., Arias O; Department of Bioengineering, University of Washington, Seattle, Washington, USA., Bashmail A; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA., Gonzalez G; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA., Roy D; Department of Bioengineering, University of Washington, Seattle, Washington, USA., Lee B; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA., Snyder JM; Department of Comparative Medicine, University of Washington, Seattle, Washington, USA., Doorn I; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA., Baker SM; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA., Wright SW; Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Washington, Seattle, Washington, USA., West TE; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA., Skerrett SJ; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA., Stayton PS; Department of Bioengineering, University of Washington, Seattle, Washington, USA.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2026 Feb 04; Vol. 70 (2), pp. e0036325. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
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  Data: An alveolar macrophage-targeted ciprofloxacin polymeric prodrug improves survival in a murine model of Klebsiella pneumoniae pneumonia.
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  Data: <searchLink fieldCode="AU" term="%22López+CL%22">López CL</searchLink>; Department of Bioengineering, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Rerolle+G%22">Rerolle G</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Snyder+S%22">Snyder S</searchLink>; Department of Bioengineering, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Arias+O%22">Arias O</searchLink>; Department of Bioengineering, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Bashmail+A%22">Bashmail A</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez+G%22">Gonzalez G</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Roy+D%22">Roy D</searchLink>; Department of Bioengineering, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Lee+B%22">Lee B</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Snyder+JM%22">Snyder JM</searchLink>; Department of Comparative Medicine, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Doorn+I%22">Doorn I</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Baker+SM%22">Baker SM</searchLink>; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Wright+SW%22">Wright SW</searchLink>; Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22West+TE%22">West TE</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Skerrett+SJ%22">Skerrett SJ</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Stayton+PS%22">Stayton PS</searchLink>; Department of Bioengineering, University of Washington, Seattle, Washington, USA.
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  Data: <searchLink fieldCode="JN" term="%220315061%22">Antimicrobial agents and chemotherapy</searchLink> [Antimicrob Agents Chemother] 2026 Feb 04; Vol. 70 (2), pp. e0036325. <i>Date of Electronic Publication: </i>2025 Dec 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Microbiology%22">American Society for Microbiology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0315061 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1098-6596 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200664804%22">00664804 </searchLink><i>NLM ISO Abbreviation: </i>Antimicrob Agents Chemother <i>Subsets: </i>MEDLINE
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