Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry.

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Title: Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry.
Authors: Schuermans A; KU Leuven Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Leuven, Belgium. aschuerm@broadinstitute.org.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aschuerm@broadinstitute.org.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. aschuerm@broadinstitute.org., Verstraete A; KU Leuven Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Leuven, Belgium.; UZ Leuven Department of Cardiovascular Diseases, Leuven, Belgium., Lammi V; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Nakanishi T; Department of Human Genetics, McGill University, Montréal, Quebec, Canada.; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Kyoto-McGill International Collaborative Program in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.; Japan Society for the Promotion of Science, Tokyo, Japan., Ardissino M; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Van den Eynde J; KU Leuven Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Leuven, Belgium., Sun BB; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Human Genetics, Informatics and Predictive Sciences, Research, Bristol Myers Squibb, Boston, MA, USA., Georgakis MK; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Stroke and Dementia Research, Ludwig Maximilian University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Guillen-Guio B; Department of Population Health Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Wain LV; Department of Population Health Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Brightling CE; NIHR Leicester Biomedical Research Centre, Leicester, UK.; Institute for Lung Health, Department of Respiratory Sciences, University of Leicester, Leicester, UK., Van Weyenbergh J; Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium., Lewandowski AJ; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Raman B; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Zeberg H; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany., Ollila HM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Burgess S; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Natarajan P; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Honigberg MC; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Freson K; KU Leuven Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Leuven, Belgium., Vanassche T; KU Leuven Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Leuven, Belgium.; UZ Leuven Department of Cardiovascular Diseases, Leuven, Belgium., Verhamme P; KU Leuven Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Leuven, Belgium.; UZ Leuven Department of Cardiovascular Diseases, Leuven, Belgium.
Corporate Authors: PHOSP-COVID Collaborative Group
Source: Nature cardiovascular research [Nat Cardiovasc Res] 2025 Dec; Vol. 4 (12), pp. 1662-1676. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918284280206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-0590 (Electronic) Linking ISSN: 27310590 NLM ISO Abbreviation: Nat Cardiovasc Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2731-0590
DOI:10.1038/s44161-025-00749-4