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Menopausal hormone therapy and the risk of breast cancer in women with a pathogenic variant in BRCA1 or BRCA2.

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Title: Menopausal hormone therapy and the risk of breast cancer in women with a pathogenic variant in BRCA1 or BRCA2.
Authors: Kotsopoulos J; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Seca M; Department of Medicine and Surgery, University of Milan, Bicocca, Milan, Italy., Gronwald J; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland., Huzarski T; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland., Møller P; Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway., Kim RH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Singer CF; Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Karlan B; Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States., Aeilts A; Division of Human Genetics, The Ohio State University Medical Center Comprehensive Cancer Center, Columbus, OH, United States., Ramón Y Cajal T; Medical Oncology, Sant Pau Campus Salut, Barcelona, Spain., Pal T; Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, United States., Eisen A; Department of Medical Oncology, Sunnybrook Odette Cancer Center, University of Toronto, Toronto, ON, Canada.; Department of Oncology, Juravinski Cancer Centre and McMaster University, Hamilton, ON, Canada., Bordeleau L; Department of Oncology, Juravinski Cancer Centre and McMaster University, Hamilton, ON, Canada., Foulkes WD; Department of Oncology, McGill Program in Cancer Genetics, McGill University, Montreal, QC, Canada., Tung N; Beth Israel Deaconess Medical Center, Cancer Risk and Prevention Program, Boston, MA, United States., Couch F; Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States., Neuhausen SL; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, United States., Zakalik D; Grosfeld Cancer Genetics Center, Beaumont Health, Oakland University William Beaumont School of Medicine, Royal Oak, MI, United States., Cybulski C; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland., Olopade O; Department of Medicine and Human Genetics, University of Chicago, Chicago, IL, United States., Metcalfe K; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.; Bloomberg School of Nursing, University of Toronto, Toronto, ON, Canada., Fruscio R; Department of Medicine and Surgery, University of Milan, Bicocca, Milan, Italy.; UO Gynecology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Sun P; Women's College Research Institute, University of Toronto, Toronto, ON, Canada., Lubinski J; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland., Narod SA; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Source: Journal of the National Cancer Institute [J Natl Cancer Inst] 2026 May 01; Vol. 118 (5), pp. 856-864.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 7503089 Publication Model: Print Cited Medium: Internet ISSN: 1460-2105 (Electronic) Linking ISSN: 00278874 NLM ISO Abbreviation: J Natl Cancer Inst Subsets: MEDLINE
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  Data: Menopausal hormone therapy and the risk of breast cancer in women with a pathogenic variant in BRCA1 or BRCA2.
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  Data: <searchLink fieldCode="AU" term="%22Kotsopoulos+J%22">Kotsopoulos J</searchLink>; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Seca+M%22">Seca M</searchLink>; Department of Medicine and Surgery, University of Milan, Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gronwald+J%22">Gronwald J</searchLink>; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.<br /><searchLink fieldCode="AU" term="%22Huzarski+T%22">Huzarski T</searchLink>; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.<br /><searchLink fieldCode="AU" term="%22Møller+P%22">Møller P</searchLink>; Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Kim+RH%22">Kim RH</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Singer+CF%22">Singer CF</searchLink>; Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Karlan+B%22">Karlan B</searchLink>; Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.<br /><searchLink fieldCode="AU" term="%22Aeilts+A%22">Aeilts A</searchLink>; Division of Human Genetics, The Ohio State University Medical Center Comprehensive Cancer Center, Columbus, OH, United States.<br /><searchLink fieldCode="AU" term="%22Ramón+Y+Cajal+T%22">Ramón Y Cajal T</searchLink>; Medical Oncology, Sant Pau Campus Salut, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pal+T%22">Pal T</searchLink>; Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Eisen+A%22">Eisen A</searchLink>; Department of Medical Oncology, Sunnybrook Odette Cancer Center, University of Toronto, Toronto, ON, Canada.; Department of Oncology, Juravinski Cancer Centre and McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bordeleau+L%22">Bordeleau L</searchLink>; Department of Oncology, Juravinski Cancer Centre and McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Foulkes+WD%22">Foulkes WD</searchLink>; Department of Oncology, McGill Program in Cancer Genetics, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Tung+N%22">Tung N</searchLink>; Beth Israel Deaconess Medical Center, Cancer Risk and Prevention Program, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Couch+F%22">Couch F</searchLink>; Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Neuhausen+SL%22">Neuhausen SL</searchLink>; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, United States.<br /><searchLink fieldCode="AU" term="%22Zakalik+D%22">Zakalik D</searchLink>; Grosfeld Cancer Genetics Center, Beaumont Health, Oakland University William Beaumont School of Medicine, Royal Oak, MI, United States.<br /><searchLink fieldCode="AU" term="%22Cybulski+C%22">Cybulski C</searchLink>; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.<br /><searchLink fieldCode="AU" term="%22Olopade+O%22">Olopade O</searchLink>; Department of Medicine and Human Genetics, University of Chicago, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Metcalfe+K%22">Metcalfe K</searchLink>; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.; Bloomberg School of Nursing, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Fruscio+R%22">Fruscio R</searchLink>; Department of Medicine and Surgery, University of Milan, Bicocca, Milan, Italy.; UO Gynecology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Sun+P%22">Sun P</searchLink>; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lubinski+J%22">Lubinski J</searchLink>; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.<br /><searchLink fieldCode="AU" term="%22Narod+SA%22">Narod SA</searchLink>; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
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