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Alanine Mutagenesis Identifies Specific Amino Acids of Nemertide Alpha-1 Activity and Its Binding to Target Receptors.

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Title: Alanine Mutagenesis Identifies Specific Amino Acids of Nemertide Alpha-1 Activity and Its Binding to Target Receptors.
Authors: Laborde Q; Pharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden., Peigneur S; Toxicology & Pharmacology, University of Leuven (KU Leuven), O&N 2, PO Box 922, Herestraat 49, 3000, Leuven, Belgium.; University of Vienna, Faculty of Chemistry, Institute of Biological Chemistry, Währinger Straße 38, 1090, Vienna, Austria., Jacobsson E; Pharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden., Göransson U; Pharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden., Tytgat J; Toxicology & Pharmacology, University of Leuven (KU Leuven), O&N 2, PO Box 922, Herestraat 49, 3000, Leuven, Belgium., Andersson HS; Pharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden.; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
Source: Journal of natural products [J Nat Prod] 2026 Jan 23; Vol. 89 (1), pp. 95-103. Date of Electronic Publication: 2025 Dec 17.
Publication Type: Journal Article
Journal Info: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Laborde+Q%22">Laborde Q</searchLink>; Pharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Peigneur+S%22">Peigneur S</searchLink>; Toxicology & Pharmacology, University of Leuven (KU Leuven), O&N 2, PO Box 922, Herestraat 49, 3000, Leuven, Belgium.; University of Vienna, Faculty of Chemistry, Institute of Biological Chemistry, Währinger Straße 38, 1090, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Jacobsson+E%22">Jacobsson E</searchLink>; Pharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Göransson+U%22">Göransson U</searchLink>; Pharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Tytgat+J%22">Tytgat J</searchLink>; Toxicology & Pharmacology, University of Leuven (KU Leuven), O&N 2, PO Box 922, Herestraat 49, 3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Andersson+HS%22">Andersson HS</searchLink>; Pharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden.; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
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  Data: <searchLink fieldCode="JN" term="%227906882%22">Journal of natural products</searchLink> [J Nat Prod] 2026 Jan 23; Vol. 89 (1), pp. 95-103. <i>Date of Electronic Publication: </i>2025 Dec 17.
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