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Selective B-cell subset depletion underlies increased infection risk in patients with MM treated with anti-BCMA vs anti-GPRC5D bsAbs.

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Title: Selective B-cell subset depletion underlies increased infection risk in patients with MM treated with anti-BCMA vs anti-GPRC5D bsAbs.
Authors: Jelinek T; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.; Sylvester Comprehensive Cancer Center, Myeloma Research Institute, University of Miami, Miami, FL., Zihala D; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.; Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic., Zabaleta A; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain., Kostopoulos IV; Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Athens, Greece., Soucek O; Department of Immunology, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic., Venglar O; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic., Moreno C; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain., Fotiou D; Plasma Cell Dyscrasia Unit, Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece., Radova E; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic., Tamariz-Amador LE; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain., Theodorakakou F; Plasma Cell Dyscrasia Unit, Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece., Muronova L; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic., Manubens A; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain., Tsitsilonis O; Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Athens, Greece., Popkova T; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic., Gonzalez C; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain., Anilkumar Sithara A; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.; Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic., Corrado F; Center for Early Detection and Interception, Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Bidikian N; Center for Early Detection and Interception, Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Guerrero C; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain., Kapustova V; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic., Bilek D; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.; Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic., Hagner PR; Bristol Myers Squibb, Summit, NJ., Larrayoz M; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain., Martinez Climent JA; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain., Broskevicova L; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic., Mihalyova J; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic., Merz M; Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, NY., Sevcikova T; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.; Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic., Ghobrial IM; Center for Early Detection and Interception, Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., San Miguel J; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain., Dimopoulos MA; Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Department of Medicine, Korea University, Seoul, South Korea., Rodriguez-Otero P; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain., Radocha J; Fourth Department of Internal Medicine-Hematology, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic., Kastritis E; Plasma Cell Dyscrasia Unit, Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece., Paiva B; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain., Hajek R; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
Source: Blood [Blood] 2026 Mar 05; Vol. 147 (10), pp. 1070-1082.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Selective B-cell subset depletion underlies increased infection risk in patients with MM treated with anti-BCMA vs anti-GPRC5D bsAbs.
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  Data: <searchLink fieldCode="AU" term="%22Jelinek+T%22">Jelinek T</searchLink>; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.; Sylvester Comprehensive Cancer Center, Myeloma Research Institute, University of Miami, Miami, FL.<br /><searchLink fieldCode="AU" term="%22Zihala+D%22">Zihala D</searchLink>; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.; Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Zabaleta+A%22">Zabaleta A</searchLink>; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Kostopoulos+IV%22">Kostopoulos IV</searchLink>; Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Soucek+O%22">Soucek O</searchLink>; Department of Immunology, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Venglar+O%22">Venglar O</searchLink>; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Moreno+C%22">Moreno C</searchLink>; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Fotiou+D%22">Fotiou D</searchLink>; Plasma Cell Dyscrasia Unit, Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Radova+E%22">Radova E</searchLink>; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Tamariz-Amador+LE%22">Tamariz-Amador LE</searchLink>; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Theodorakakou+F%22">Theodorakakou F</searchLink>; Plasma Cell Dyscrasia Unit, Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Muronova+L%22">Muronova L</searchLink>; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Manubens+A%22">Manubens A</searchLink>; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Tsitsilonis+O%22">Tsitsilonis O</searchLink>; Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Popkova+T%22">Popkova T</searchLink>; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Gonzalez+C%22">Gonzalez C</searchLink>; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Anilkumar+Sithara+A%22">Anilkumar Sithara A</searchLink>; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.; Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Corrado+F%22">Corrado F</searchLink>; Center for Early Detection and Interception, Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Bidikian+N%22">Bidikian N</searchLink>; Center for Early Detection and Interception, Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Guerrero+C%22">Guerrero C</searchLink>; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Kapustova+V%22">Kapustova V</searchLink>; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Bilek+D%22">Bilek D</searchLink>; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.; Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Hagner+PR%22">Hagner PR</searchLink>; Bristol Myers Squibb, Summit, NJ.<br /><searchLink fieldCode="AU" term="%22Larrayoz+M%22">Larrayoz M</searchLink>; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez+Climent+JA%22">Martinez Climent JA</searchLink>; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Broskevicova+L%22">Broskevicova L</searchLink>; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Mihalyova+J%22">Mihalyova J</searchLink>; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Merz+M%22">Merz M</searchLink>; Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Sevcikova+T%22">Sevcikova T</searchLink>; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.; Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Ghobrial+IM%22">Ghobrial IM</searchLink>; Center for Early Detection and Interception, Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22San+Miguel+J%22">San Miguel J</searchLink>; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Dimopoulos+MA%22">Dimopoulos MA</searchLink>; Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Department of Medicine, Korea University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Otero+P%22">Rodriguez-Otero P</searchLink>; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Radocha+J%22">Radocha J</searchLink>; Fourth Department of Internal Medicine-Hematology, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kastritis+E%22">Kastritis E</searchLink>; Plasma Cell Dyscrasia Unit, Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Paiva+B%22">Paiva B</searchLink>; Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Hajek+R%22">Hajek R</searchLink>; Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
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