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A BRN2:MYC transcriptional axis regulates interconversion between therapy-resistant and tumorigenic phenotypes in melanoma.

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Title: A BRN2:MYC transcriptional axis regulates interconversion between therapy-resistant and tumorigenic phenotypes in melanoma.
Authors: Zhang Y; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA., Urquijo MA; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT 84103, USA., Zitnay RG; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Molecular Genetics, The Ohio State University College of Arts and Sciences, Columbus, OH 43210, USA; Department of Chemical Engineering, University of Utah, Salt Lake City, UT 84103, USA., Marks K; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Belote RL; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Molecular Genetics, The Ohio State University College of Arts and Sciences, Columbus, OH 43210, USA., Hansen MMK; Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, the Netherlands., Ferita M; Department of Mathematics, University of Utah, Salt Lake City, UT, USA., Neuendorf HM; Cancer Drug Mechanisms Group, Cancer Research Department, QIMR Berghofer, Brisbane, QLD 4006, Australia; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD 4059, Australia., Liu T; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Smith EA; Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA., Mehrabad EM; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA., Hejna M; Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Moustafa TE; Department of Chemical Engineering, University of Utah, Salt Lake City, UT 84103, USA., Lange D; SCI Institute and Kahlert School of Computing, University of Utah, Salt Lake City, UT 84112, USA., Hu M; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT 84103, USA., Vand-Rajabpour F; Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Done A; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Becker CA; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Lieberman M; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA., Chang M; Department of Dermatology, Oregon Health and Science University, Portland, OR 97239, USA; Departments of Biomedical Engineering and Oncological Sciences, Oregon Health and Science University, Portland, OR 97239, USA; Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA; Operative Care Division, VA Portland Health Care System, Portland, OR 97239, USA., Lohman BK; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA., Stubben CJ; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA., Reeves MQ; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA., Zhang X; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT 84103, USA., Weinberger LS; Gladstone Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA; Departments of Pharmaceutical Chemistry and Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA., VanBrocklin MW; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Deacon DC; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Grossman D; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Spike BT; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT 84103, USA., Lex A; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; SCI Institute and Kahlert School of Computing, University of Utah, Salt Lake City, UT 84112, USA., Boyle GM; Cancer Drug Mechanisms Group, Cancer Research Department, QIMR Berghofer, Brisbane, QLD 4006, Australia; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD 4059, Australia; School of Biomedical Science, Faculty of Health, Medicine and Behavioral Sciences, University of Queensland, Brisbane, QLD 4072, Australia., Kulkarni R; Department of Dermatology, Oregon Health and Science University, Portland, OR 97239, USA; Departments of Biomedical Engineering and Oncological Sciences, Oregon Health and Science University, Portland, OR 97239, USA; Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA; Operative Care Division, VA Portland Health Care System, Portland, OR 97239, USA., Zangle TA; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Chemical Engineering, University of Utah, Salt Lake City, UT 84103, USA., Judson-Torres RL; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT 84103, USA; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA. Electronic address: robert.judson-torres@hci.utah.edu.
Source: Cell reports [Cell Rep] 2025 Dec 23; Vol. 44 (12), pp. 116675. Date of Electronic Publication: 2025 Dec 15.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: A BRN2:MYC transcriptional axis regulates interconversion between therapy-resistant and tumorigenic phenotypes in melanoma.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Urquijo+MA%22">Urquijo MA</searchLink>; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT 84103, USA.<br /><searchLink fieldCode="AU" term="%22Zitnay+RG%22">Zitnay RG</searchLink>; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Molecular Genetics, The Ohio State University College of Arts and Sciences, Columbus, OH 43210, USA; Department of Chemical Engineering, University of Utah, Salt Lake City, UT 84103, USA.<br /><searchLink fieldCode="AU" term="%22Marks+K%22">Marks K</searchLink>; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.<br /><searchLink fieldCode="AU" term="%22Belote+RL%22">Belote RL</searchLink>; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Molecular Genetics, The Ohio State University College of Arts and Sciences, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Hansen+MMK%22">Hansen MMK</searchLink>; Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ferita+M%22">Ferita M</searchLink>; Department of Mathematics, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Neuendorf+HM%22">Neuendorf HM</searchLink>; Cancer Drug Mechanisms Group, Cancer Research Department, QIMR Berghofer, Brisbane, QLD 4006, Australia; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD 4059, Australia.<br /><searchLink fieldCode="AU" term="%22Liu+T%22">Liu T</searchLink>; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.<br /><searchLink fieldCode="AU" term="%22Smith+EA%22">Smith EA</searchLink>; Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA.<br /><searchLink fieldCode="AU" term="%22Mehrabad+EM%22">Mehrabad EM</searchLink>; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.<br /><searchLink fieldCode="AU" term="%22Hejna+M%22">Hejna M</searchLink>; Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Carl R. 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