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Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses.

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Title: Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses.
Authors: Castaño D; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bettini E; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kumar B; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chudnovskiy A; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA., Siv A; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Protti G; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy., Nakadakari-Higa S; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA., Ceglia S; Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA., De Luna N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chiu JE; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lederer K; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Li SH; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ibrahim H; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Muramatsu H; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mdluli T; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Abraham E; Synthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary; National Laboratory for Biotechnology, Institute of Genetics, HUN-REN Biological Research Centre, Szeged, Hungary., Sahingur SE; Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA., Maillard I; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tam YK; Acuitas Therapeutics, Vancouver, BC, Canada., Shin S; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hensley SE; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Miner JJ; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Rheumatology, Department of Medicine, RVCL Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lipinszki Z; Synthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary; National Laboratory for Biotechnology, Institute of Genetics, HUN-REN Biological Research Centre, Szeged, Hungary; ATGandCo Biotechnology Ltd, Mórahalom, Hungary., Reboldi A; Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Pardi N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Spreafico R; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA., Victora GD; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA., Locci M; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: michela.locci@pennmedicine.upenn.edu.
Source: Cell [Cell] 2025 Dec 24; Vol. 188 (26), pp. 7461-7480.e23. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses.
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  Data: <searchLink fieldCode="AU" term="%22Castaño+D%22">Castaño D</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bettini+E%22">Bettini E</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+B%22">Kumar B</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chudnovskiy+A%22">Chudnovskiy A</searchLink>; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Siv+A%22">Siv A</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Protti+G%22">Protti G</searchLink>; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Nakadakari-Higa+S%22">Nakadakari-Higa S</searchLink>; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ceglia+S%22">Ceglia S</searchLink>; Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22De+Luna+N%22">De Luna N</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chiu+JE%22">Chiu JE</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lederer+K%22">Lederer K</searchLink>; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Li+SH%22">Li SH</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ibrahim+H%22">Ibrahim H</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Muramatsu+H%22">Muramatsu H</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mdluli+T%22">Mdluli T</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Abraham+E%22">Abraham E</searchLink>; Synthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary; National Laboratory for Biotechnology, Institute of Genetics, HUN-REN Biological Research Centre, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Sahingur+SE%22">Sahingur SE</searchLink>; Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Maillard+I%22">Maillard I</searchLink>; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tam+YK%22">Tam YK</searchLink>; Acuitas Therapeutics, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Shin+S%22">Shin S</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hensley+SE%22">Hensley SE</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Miner+JJ%22">Miner JJ</searchLink>; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Rheumatology, Department of Medicine, RVCL Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lipinszki+Z%22">Lipinszki Z</searchLink>; Synthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary; National Laboratory for Biotechnology, Institute of Genetics, HUN-REN Biological Research Centre, Szeged, Hungary; ATGandCo Biotechnology Ltd, Mórahalom, Hungary.<br /><searchLink fieldCode="AU" term="%22Reboldi+A%22">Reboldi A</searchLink>; Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pardi+N%22">Pardi N</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Spreafico+R%22">Spreafico R</searchLink>; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Victora+GD%22">Victora GD</searchLink>; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Locci+M%22">Locci M</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: michela.locci@pennmedicine.upenn.edu.
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