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A multicenter trial to test pitavastatin calcium in youth with combined dyslipidemia of obesity: Design, implementation, challenges, and responses.

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Title: A multicenter trial to test pitavastatin calcium in youth with combined dyslipidemia of obesity: Design, implementation, challenges, and responses.
Authors: de Ferranti SD; Boston Children's Hospital, Harvard Medical School, Boston, MA. Electronic address: Sarah.deferranti@cardio.chboston.org., Teng JE; Carelon Research, Newton, MA., Arslanian SA; Faculty Pavilion-Lawrenceville, University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh, Pittsburgh, PA., Atz AM; Medical University of South Carolina, Charleston SC., Brothers JA; Children's Hospital of Philadelphia, Philadelphia, PA., Cartoski MJ; Nemours Children's Health, Wilmington, DE., Freemon DR; National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD., Magge SN; Johns Hopkins University School of Medicine, Baltimore, MD., Mahle WT; Children's Healthcare of Atlanta Cardiology, Atlanta, GA., Mietus-Snyder M; Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington DC., Peterson A; University of Wisconsin School of Medicine and Public Health, Madison, WI., Raghuveer G; Children's Mercy Hospital, University of Missouri Kansas City School of Medicine, Kansas City, MO., Russell MW; CS Mott Children's Hospital, University of Michigan, Ann Arbor, MI., Shah AS; Cincinnati Children's Hospital Medical Center & The University of Cincinnati, Cincinnati, OH, United States., Sponseller CA; Kowa Pharmaceuticals America, Inc., Montgomery, AL., Stylianou M; National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD., Trachtenberg FL; Carelon Research, Newton, MA., Urbina EM; University of Cincinnati College of Medicine, Cincinnati, OH., Ware AL; University of Utah, Salt Lake City, UT., Zachariah J; Texas Children's Hospital, Baylor College of Medicine, South Texas Children's Hospital, The Woodlands, TX., Zadokar VV; Nemours Children's Health, Wilmington, DE., McCrindle BW; Division of Cardiology/Labatt Heart Centre, The Hospital for Sick Children Toronto, Ontario Canada.
Corporate Authors: Pediatric Heart Network Investigators
Source: American heart journal [Am Heart J] 2026 Apr; Vol. 294, pp. 107327. Date of Electronic Publication: 2025 Dec 15.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 0370465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6744 (Electronic) Linking ISSN: 00028703 NLM ISO Abbreviation: Am Heart J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22de+Ferranti+SD%22">de Ferranti SD</searchLink>; Boston Children's Hospital, Harvard Medical School, Boston, MA. Electronic address: Sarah.deferranti@cardio.chboston.org.<br /><searchLink fieldCode="AU" term="%22Teng+JE%22">Teng JE</searchLink>; Carelon Research, Newton, MA.<br /><searchLink fieldCode="AU" term="%22Arslanian+SA%22">Arslanian SA</searchLink>; Faculty Pavilion-Lawrenceville, University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Atz+AM%22">Atz AM</searchLink>; Medical University of South Carolina, Charleston SC.<br /><searchLink fieldCode="AU" term="%22Brothers+JA%22">Brothers JA</searchLink>; Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Cartoski+MJ%22">Cartoski MJ</searchLink>; Nemours Children's Health, Wilmington, DE.<br /><searchLink fieldCode="AU" term="%22Freemon+DR%22">Freemon DR</searchLink>; National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Magge+SN%22">Magge SN</searchLink>; Johns Hopkins University School of Medicine, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Mahle+WT%22">Mahle WT</searchLink>; Children's Healthcare of Atlanta Cardiology, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Mietus-Snyder+M%22">Mietus-Snyder M</searchLink>; Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington DC.<br /><searchLink fieldCode="AU" term="%22Peterson+A%22">Peterson A</searchLink>; University of Wisconsin School of Medicine and Public Health, Madison, WI.<br /><searchLink fieldCode="AU" term="%22Raghuveer+G%22">Raghuveer G</searchLink>; Children's Mercy Hospital, University of Missouri Kansas City School of Medicine, Kansas City, MO.<br /><searchLink fieldCode="AU" term="%22Russell+MW%22">Russell MW</searchLink>; CS Mott Children's Hospital, University of Michigan, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Shah+AS%22">Shah AS</searchLink>; Cincinnati Children's Hospital Medical Center & The University of Cincinnati, Cincinnati, OH, United States.<br /><searchLink fieldCode="AU" term="%22Sponseller+CA%22">Sponseller CA</searchLink>; Kowa Pharmaceuticals America, Inc., Montgomery, AL.<br /><searchLink fieldCode="AU" term="%22Stylianou+M%22">Stylianou M</searchLink>; National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Trachtenberg+FL%22">Trachtenberg FL</searchLink>; Carelon Research, Newton, MA.<br /><searchLink fieldCode="AU" term="%22Urbina+EM%22">Urbina EM</searchLink>; University of Cincinnati College of Medicine, Cincinnati, OH.<br /><searchLink fieldCode="AU" term="%22Ware+AL%22">Ware AL</searchLink>; University of Utah, Salt Lake City, UT.<br /><searchLink fieldCode="AU" term="%22Zachariah+J%22">Zachariah J</searchLink>; Texas Children's Hospital, Baylor College of Medicine, South Texas Children's Hospital, The Woodlands, TX.<br /><searchLink fieldCode="AU" term="%22Zadokar+VV%22">Zadokar VV</searchLink>; Nemours Children's Health, Wilmington, DE.<br /><searchLink fieldCode="AU" term="%22McCrindle+BW%22">McCrindle BW</searchLink>; Division of Cardiology/Labatt Heart Centre, The Hospital for Sick Children Toronto, Ontario Canada.
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  Data: <searchLink fieldCode="JN" term="%220370465%22">American heart journal</searchLink> [Am Heart J] 2026 Apr; Vol. 294, pp. 107327. <i>Date of Electronic Publication: </i>2025 Dec 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Mosby%22">Mosby </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0370465 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-6744 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200028703%22">00028703 </searchLink><i>NLM ISO Abbreviation: </i>Am Heart J <i>Subsets: </i>MEDLINE
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