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Can we Save the rectum by watchful waiting or transanal microsurgery following shorT-course radiotherapy and Additional local oR systemic Treatment for early-stage REctal Cancer? STARTREC-3 protocol for a non-randomised, multicentre, phase II platform study.

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Title: Can we Save the rectum by watchful waiting or transanal microsurgery following shorT-course radiotherapy and Additional local oR systemic Treatment for early-stage REctal Cancer? STARTREC-3 protocol for a non-randomised, multicentre, phase II platform study.
Authors: de Vries SEN; Department of Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands., Couwenberg AM; Department of Radiotherapy, Netherlands Cancer Institute, Amsterdam, The Netherlands., Marijnen CAM; Department of Radiotherapy, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Radiotherapy, LUMC, Leiden, The Netherlands., Beets GL; Department of Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Surgery, Maastricht University Medical Centre+, Maastricht, The Netherlands., Burger JW; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands., Chalabi M; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., de Groot JW; Department of Medical Oncology, Isala Hospital, Zwolle, The Netherlands., Intven M; Department of Radiotherapy, University Medical Centre Utrecht, Utrecht, The Netherlands., Peulen HM; Department of Radiotherapy, Catharina Hospital, Eindhoven, The Netherlands., Roodhart JML; Department of Medical Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands., de Wilt JHW; Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands., Grotenhuis BA; Department of Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands b.grotenhuis@nki.nl.
Source: BMJ open [BMJ Open] 2025 Dec 17; Vol. 15 (12), pp. e111711. Date of Electronic Publication: 2025 Dec 17.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: Can we Save the rectum by watchful waiting or transanal microsurgery following shorT-course radiotherapy and Additional local oR systemic Treatment for early-stage REctal Cancer? STARTREC-3 protocol for a non-randomised, multicentre, phase II platform study.
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  Data: <searchLink fieldCode="AU" term="%22de+Vries+SEN%22">de Vries SEN</searchLink>; Department of Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Couwenberg+AM%22">Couwenberg AM</searchLink>; Department of Radiotherapy, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Marijnen+CAM%22">Marijnen CAM</searchLink>; Department of Radiotherapy, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Radiotherapy, LUMC, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Beets+GL%22">Beets GL</searchLink>; Department of Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Surgery, Maastricht University Medical Centre+, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Burger+JW%22">Burger JW</searchLink>; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Chalabi+M%22">Chalabi M</searchLink>; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Groot+JW%22">de Groot JW</searchLink>; Department of Medical Oncology, Isala Hospital, Zwolle, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Intven+M%22">Intven M</searchLink>; Department of Radiotherapy, University Medical Centre Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Peulen+HM%22">Peulen HM</searchLink>; Department of Radiotherapy, Catharina Hospital, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Roodhart+JML%22">Roodhart JML</searchLink>; Department of Medical Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Wilt+JHW%22">de Wilt JHW</searchLink>; Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Grotenhuis+BA%22">Grotenhuis BA</searchLink>; Department of Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands b.grotenhuis@nki.nl.
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  Data: <searchLink fieldCode="JN" term="%22101552874%22">BMJ open</searchLink> [BMJ Open] 2025 Dec 17; Vol. 15 (12), pp. e111711. <i>Date of Electronic Publication: </i>2025 Dec 17.
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