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An integrated view of the structure and function of the human 4D nucleome.

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Title: An integrated view of the structure and function of the human 4D nucleome.
Authors: Dekker J; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. job.dekker@umassmed.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. job.dekker@umassmed.edu., Oksuz BA; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Zhang Y; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Wang Y; Department of Microbiology, Immunology, and Molecular Genetics, Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA, USA., Minsk MK; Department of Genetics, Department of Bioengineering, Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA., Kuang S; Gladstone Institutes, San Francisco, CA, USA., Yang L; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Gibcus JH; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Krietenstein N; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark., Rando OJ; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Xu J; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, IL, USA., Janssens DH; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA., Henikoff S; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Kukalev A; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany., Andréa W; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany., Winick-Ng W; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany., Kempfer R; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany., Pombo A; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany., Yu M; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.; State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Fudan University, Shanghai, China., Kumar P; Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Zhang L; Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Belmont AS; Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Sasaki T; San Diego Biomedical Research Institute, San Diego, CA, USA., van Schaik T; Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Brueckner L; Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands., Peric-Hupkes D; Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., van Steensel B; Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Wang P; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, IL, USA., Chai H; Life Sciences Institute, Zhejiang University, Hangzhou, P.R. China., Kim M; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Ruan Y; Life Sciences Institute, Zhejiang University, Hangzhou, P.R. China., Zhang R; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Quinodoz SA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA., Bhat P; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Guttman M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Zhao W; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA., Chien S; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA., Liu Y; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA., Venev SV; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Plewczynski D; Laboratory of Bioinformatics and Computational Genomics, Faculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland.; Laboratory of Functional and Structural Genomics, Centre of New Technologies, University of Warsaw, Warsaw, Poland., Azcarate II; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany., Szabó D; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany., Thieme CJ; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany., Szczepińska T; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.; Laboratory of Functional and Structural Genomics, Centre of New Technologies, University of Warsaw, Warsaw, Poland.; Centre for Advanced Materials and Technologies CEZAMAT, Warsaw University of Technology, Warsaw, Poland., Chiliński M; Laboratory of Bioinformatics and Computational Genomics, Faculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland., Sengupta K; Laboratory of Bioinformatics and Computational Genomics, Faculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland., Conte M; Department of Physics, University of Naples 'Federico II', and INFN, Naples, Italy., Esposito A; Department of Physics, University of Naples 'Federico II', and INFN, Naples, Italy., Abraham A; Department of Physics, University of Naples 'Federico II', and INFN, Naples, Italy., Zhang R; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Wang Y; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Wen X; Program in Bioinformatics and Systems Biology, University of California San Diego, La Jolla, CA, USA., Wu Q; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA., Yang Y; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Liu J; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Boninsegna L; Department of Microbiology, Immunology, and Molecular Genetics, Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA, USA., Yildirim A; Department of Microbiology, Immunology, and Molecular Genetics, Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA, USA., Zhan Y; Department of Microbiology, Immunology, and Molecular Genetics, Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA, USA., Chiariello AM; Department of Physics, University of Naples 'Federico II', and INFN, Naples, Italy., Bianco S; Department of Physics, University of Naples 'Federico II', and INFN, Naples, Italy., Lee L; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA., Hu M; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA., Li Y; Department of Biostatistics, Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Barnett RJ; Department of Genetics, Department of Bioengineering, Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA., Cook AL; Department of Genetics, Department of Bioengineering, Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA., Emerson DJ; Department of Genetics, Department of Bioengineering, Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA., Marchal C; In silichrom Ltd, Newbury, UK., Zhao P; San Diego Biomedical Research Institute, San Diego, CA, USA., Park PJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Alver BH; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Schroeder AJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Navelkar R; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Bakker C; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Ronchetti W; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Ehmsen S; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Veit AD; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Gehlenborg N; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Wang T; Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Li D; Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Wang X; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, IL, USA. wangxiaotao@fudan.edu.cn.; Institute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China. wangxiaotao@fudan.edu.cn., Nicodemi M; Department of Physics, University of Naples 'Federico II', and INFN, Naples, Italy. mario.nicodemi@na.infn.it., Ren B; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA. bren@nygenome.org., Zhong S; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA. szhong@ucsd.edu., Phillips-Cremins JE; Department of Genetics, Department of Bioengineering, Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA. jennifer.cremins@wustl.edu., Gilbert DM; San Diego Biomedical Research Institute, San Diego, CA, USA. gilbert@sdbri.org., Pollard KS; Gladstone Institutes, San Francisco, CA, USA. katherine.pollard@gladstone.ucsf.edu., Alber F; Department of Microbiology, Immunology, and Molecular Genetics, Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA, USA. falber@g.ucla.edu., Ma J; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA. jianma@cs.cmu.edu., Noble WS; Department of Genome Sciences, University of Washington, Seattle, WA, USA. william-noble@uw.edu., Yue F; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, IL, USA. Yue@northwestern.edu.; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA. Yue@northwestern.edu.
Source: Nature [Nature] 2026 Jan; Vol. 649 (8097), pp. 759-776. Date of Electronic Publication: 2025 Dec 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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  Data: An integrated view of the structure and function of the human 4D nucleome.
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  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Dekker+J%22">Dekker J</searchLink>; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. job.dekker@umassmed.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. job.dekker@umassmed.edu.<br /><searchLink fieldCode="AU" term="%22Oksuz+BA%22">Oksuz BA</searchLink>; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Microbiology, Immunology, and Molecular Genetics, Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Minsk+MK%22">Minsk MK</searchLink>; Department of Genetics, Department of Bioengineering, Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kuang+S%22">Kuang S</searchLink>; Gladstone Institutes, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gibcus+JH%22">Gibcus JH</searchLink>; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Krietenstein+N%22">Krietenstein N</searchLink>; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Rando+OJ%22">Rando OJ</searchLink>; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Janssens+DH%22">Janssens DH</searchLink>; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Henikoff+S%22">Henikoff S</searchLink>; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kukalev+A%22">Kukalev A</searchLink>; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Andréa+W%22">Andréa W</searchLink>; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Winick-Ng+W%22">Winick-Ng W</searchLink>; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kempfer+R%22">Kempfer R</searchLink>; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Pombo+A%22">Pombo A</searchLink>; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Yu+M%22">Yu M</searchLink>; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.; State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Kumar+P%22">Kumar P</searchLink>; Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.<br /><searchLink fieldCode="AU" term="%22Belmont+AS%22">Belmont AS</searchLink>; Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.<br /><searchLink fieldCode="AU" term="%22Sasaki+T%22">Sasaki T</searchLink>; San Diego Biomedical Research Institute, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22van+Schaik+T%22">van Schaik T</searchLink>; Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Brueckner+L%22">Brueckner L</searchLink>; Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Peric-Hupkes+D%22">Peric-Hupkes D</searchLink>; Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Steensel+B%22">van Steensel B</searchLink>; Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wang+P%22">Wang P</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Chai+H%22">Chai H</searchLink>; Life Sciences Institute, Zhejiang University, Hangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Kim+M%22">Kim M</searchLink>; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Ruan+Y%22">Ruan Y</searchLink>; Life Sciences Institute, Zhejiang University, Hangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Department of Genome Sciences, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Quinodoz+SA%22">Quinodoz SA</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Bhat+P%22">Bhat P</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Guttman+M%22">Guttman M</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chien+S%22">Chien S</searchLink>; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Venev+SV%22">Venev SV</searchLink>; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Plewczynski+D%22">Plewczynski D</searchLink>; Laboratory of Bioinformatics and Computational Genomics, Faculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland.; Laboratory of Functional and Structural Genomics, Centre of New Technologies, University of Warsaw, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Azcarate+II%22">Azcarate II</searchLink>; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Szabó+D%22">Szabó D</searchLink>; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Thieme+CJ%22">Thieme CJ</searchLink>; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Szczepińska+T%22">Szczepińska T</searchLink>; Epigenetic Regulation and Chromatin Architecture Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.; Laboratory of Functional and Structural Genomics, Centre of New Technologies, University of Warsaw, Warsaw, Poland.; Centre for Advanced Materials and Technologies CEZAMAT, Warsaw University of Technology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Chiliński+M%22">Chiliński M</searchLink>; Laboratory of Bioinformatics and Computational Genomics, Faculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Sengupta+K%22">Sengupta K</searchLink>; Laboratory of Bioinformatics and Computational Genomics, Faculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Conte+M%22">Conte M</searchLink>; Department of Physics, University of Naples 'Federico II', and INFN, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Esposito+A%22">Esposito A</searchLink>; Department of Physics, University of Naples 'Federico II', and INFN, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Abraham+A%22">Abraham A</searchLink>; Department of Physics, University of Naples 'Federico II', and INFN, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wen+X%22">Wen X</searchLink>; Program in Bioinformatics and Systems Biology, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Q%22">Wu Q</searchLink>; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Boninsegna+L%22">Boninsegna L</searchLink>; Department of Microbiology, Immunology, and Molecular Genetics, Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yildirim+A%22">Yildirim A</searchLink>; Department of Microbiology, Immunology, and Molecular Genetics, Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhan+Y%22">Zhan Y</searchLink>; Department of Microbiology, Immunology, and Molecular Genetics, Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chiariello+AM%22">Chiariello AM</searchLink>; Department of Physics, University of Naples 'Federico II', and INFN, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Bianco+S%22">Bianco S</searchLink>; Department of Physics, University of Naples 'Federico II', and INFN, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Lee+L%22">Lee L</searchLink>; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hu+M%22">Hu M</searchLink>; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Biostatistics, Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Barnett+RJ%22">Barnett RJ</searchLink>; Department of Genetics, Department of Bioengineering, Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cook+AL%22">Cook AL</searchLink>; Department of Genetics, Department of Bioengineering, Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Emerson+DJ%22">Emerson DJ</searchLink>; Department of Genetics, Department of Bioengineering, Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Marchal+C%22">Marchal C</searchLink>; In silichrom Ltd, Newbury, UK.<br /><searchLink fieldCode="AU" term="%22Zhao+P%22">Zhao P</searchLink>; San Diego Biomedical Research Institute, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Park+PJ%22">Park PJ</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Alver+BH%22">Alver BH</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schroeder+AJ%22">Schroeder AJ</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Navelkar+R%22">Navelkar R</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bakker+C%22">Bakker C</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ronchetti+W%22">Ronchetti W</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ehmsen+S%22">Ehmsen S</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Veit+AD%22">Veit AD</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gehlenborg+N%22">Gehlenborg N</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, IL, USA. wangxiaotao@fudan.edu.cn.; Institute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China. wangxiaotao@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Nicodemi+M%22">Nicodemi M</searchLink>; Department of Physics, University of Naples 'Federico II', and INFN, Naples, Italy. mario.nicodemi@na.infn.it.<br /><searchLink fieldCode="AU" term="%22Ren+B%22">Ren B</searchLink>; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA. bren@nygenome.org.<br /><searchLink fieldCode="AU" term="%22Zhong+S%22">Zhong S</searchLink>; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA. szhong@ucsd.edu.<br /><searchLink fieldCode="AU" term="%22Phillips-Cremins+JE%22">Phillips-Cremins JE</searchLink>; Department of Genetics, Department of Bioengineering, Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA. jennifer.cremins@wustl.edu.<br /><searchLink fieldCode="AU" term="%22Gilbert+DM%22">Gilbert DM</searchLink>; San Diego Biomedical Research Institute, San Diego, CA, USA. gilbert@sdbri.org.<br /><searchLink fieldCode="AU" term="%22Pollard+KS%22">Pollard KS</searchLink>; Gladstone Institutes, San Francisco, CA, USA. katherine.pollard@gladstone.ucsf.edu.<br /><searchLink fieldCode="AU" term="%22Alber+F%22">Alber F</searchLink>; Department of Microbiology, Immunology, and Molecular Genetics, Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA, USA. falber@g.ucla.edu.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA. jianma@cs.cmu.edu.<br /><searchLink fieldCode="AU" term="%22Noble+WS%22">Noble WS</searchLink>; Department of Genome Sciences, University of Washington, Seattle, WA, USA. william-noble@uw.edu.<br /><searchLink fieldCode="AU" term="%22Yue+F%22">Yue F</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, IL, USA. Yue@northwestern.edu.; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA. Yue@northwestern.edu.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 Jan; Vol. 649 (8097), pp. 759-776. <i>Date of Electronic Publication: </i>2025 Dec 17.
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