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Genetic liability to psoriasis predicts severe disease outcomes.

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Title: Genetic liability to psoriasis predicts severe disease outcomes.
Authors: Saklatvala JR; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, SE1 9RT, UK., Lessard S; Target, Disease & Systems Biology, Sanofi Research, Cambridge, MA, USA., Teder-Laving M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Thomas LF; Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; BioCore - Bioinformatics Core Facility, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Ramessur R; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Zierer J; Immunology Disease Area, Biomedical Research, Novartis Pharma AG, Basel, Switzerland., Åsvold BO; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Barton A; Centre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.; National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre, The University of Manchester, Manchester, UK.; The Kellgren Centre for Rheumatology, Manchester University NHS Foundation Trust, Manchester, UK., Baudry D; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Bowes J; Centre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.; National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre, The University of Manchester, Manchester, UK., Brumpton B; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, NO-7030, Trondheim, Norway., Bruno S; Immunology Disease Area, Biomedical Research, Novartis Pharma AG, Basel, Switzerland., Chandran V; Schroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network and Departments of Medicine/Rheumatology, Institute of Medical Science, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Chatelain C; Target, Disease & Systems Biology, Sanofi Research, Cambridge, MA, USA., de Rinaldis E; Target, Disease & Systems Biology, Sanofi Research, Cambridge, MA, USA., Elder JT; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.; Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, USA., Ellinghaus D; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Foerster J; College of Medicine, Dentistry, and Nursing, University of Dundee, Dundee, UK., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Gladman DD; Schroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network and Departments of Medicine/Rheumatology, Institute of Medical Science, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Gulliver W; Newlab Clinical Research Inc, St. John's, NL, Canada.; Department of Dermatology, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Hüffmeier U; Institute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany., Huilaja L; Department of Dermatology and Medical Research Center, Oulu University Hospital and Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland., Hveem K; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Innovation and Research, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Khader S; Target, Disease & Systems Biology, Sanofi Research, Cambridge, MA, USA., Kingo K; Faculty of Medicine, Institute of Clinical Medicine, University of Tartu, Tartu University Hospital, Tartu, Estonia., Klinger K; Genetics Research, Sanofi, Cambridge, MA, USA., Kolbinger F; Immunology Disease Area, Biomedical Research, Novartis Pharma AG, Basel, Switzerland., Kõks S; Perron Institute for Neurological and Translational Science, Nedlands, WA, 6009, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, WA, 6150, Australia., Liao W; Deparment of Dermatology, University of California San Francisco, San Francisco, CA, USA., Nair RP; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Nititham J; Deparment of Dermatology, University of California San Francisco, San Francisco, CA, USA., Rahman P; Memorial University of Newfoundland, St. John's, NL, Canada., Reis A; Institute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany., Sagoo MK; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Stuart PE; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Tasanen K; Department of Dermatology and Medical Research Center, Oulu University Hospital and Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland., Traks T; Department of Dermatology and Venereology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia., Tsoi LC; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Uebe S; Institute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany., Watts K; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK., Barker JN; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Mahil SK; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Langan SM; Faculty of Epidemiology and Population Health, London, School of Hygiene and Tropical Medicine , London, UK., Brown SJ; Centre for Genomic & Experimental Medicine, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.; Department of Dermatology, NHS Lothian, Edinburgh, UK., Løset M; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Dermatology, Clinic of Orthopedy, Rheumatology and Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Paternoster L; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK., Dand N; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, SE1 9RT, UK., Smith CH; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Simpson MA; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, SE1 9RT, UK. michael.simpson@kcl.ac.uk.
Corporate Authors: BSTOP study group, FinnGen, Estonian Biobank research team
Source: Genome medicine [Genome Med] 2025 Dec 17; Vol. 18 (1), pp. 14. Date of Electronic Publication: 2025 Dec 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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DbLabel: MEDLINE Ultimate
An: 41408349
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Genetic liability to psoriasis predicts severe disease outcomes.
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Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Ramessur+R%22">Ramessur R</searchLink>; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Zierer+J%22">Zierer J</searchLink>; Immunology Disease Area, Biomedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Åsvold+BO%22">Åsvold BO</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Barton+A%22">Barton A</searchLink>; Centre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.; 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HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, NO-7030, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Bruno+S%22">Bruno S</searchLink>; Immunology Disease Area, Biomedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chandran+V%22">Chandran V</searchLink>; Schroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network and Departments of Medicine/Rheumatology, Institute of Medical Science, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Chatelain+C%22">Chatelain C</searchLink>; Target, Disease & Systems Biology, Sanofi Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22de+Rinaldis+E%22">de Rinaldis E</searchLink>; Target, Disease & Systems Biology, Sanofi Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Elder+JT%22">Elder JT</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.; Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Ellinghaus+D%22">Ellinghaus D</searchLink>; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Foerster+J%22">Foerster J</searchLink>; College of Medicine, Dentistry, and Nursing, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Franke+A%22">Franke A</searchLink>; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Gladman+DD%22">Gladman DD</searchLink>; Schroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network and Departments of Medicine/Rheumatology, Institute of Medical Science, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Gulliver+W%22">Gulliver W</searchLink>; Newlab Clinical Research Inc, St. John's, NL, Canada.; Department of Dermatology, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.<br /><searchLink fieldCode="AU" term="%22Hüffmeier+U%22">Hüffmeier U</searchLink>; Institute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Huilaja+L%22">Huilaja L</searchLink>; Department of Dermatology and Medical Research Center, Oulu University Hospital and Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Hveem+K%22">Hveem K</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Innovation and Research, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Khader+S%22">Khader S</searchLink>; Target, Disease & Systems Biology, Sanofi Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kingo+K%22">Kingo K</searchLink>; Faculty of Medicine, Institute of Clinical Medicine, University of Tartu, Tartu University Hospital, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Klinger+K%22">Klinger K</searchLink>; Genetics Research, Sanofi, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kolbinger+F%22">Kolbinger F</searchLink>; Immunology Disease Area, Biomedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kõks+S%22">Kõks S</searchLink>; Perron Institute for Neurological and Translational Science, Nedlands, WA, 6009, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, WA, 6150, Australia.<br /><searchLink fieldCode="AU" term="%22Liao+W%22">Liao W</searchLink>; Deparment of Dermatology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nair+RP%22">Nair RP</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Nititham+J%22">Nititham J</searchLink>; Deparment of Dermatology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rahman+P%22">Rahman P</searchLink>; Memorial University of Newfoundland, St. John's, NL, Canada.<br /><searchLink fieldCode="AU" term="%22Reis+A%22">Reis A</searchLink>; Institute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Sagoo+MK%22">Sagoo MK</searchLink>; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Stuart+PE%22">Stuart PE</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Tasanen+K%22">Tasanen K</searchLink>; Department of Dermatology and Medical Research Center, Oulu University Hospital and Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Traks+T%22">Traks T</searchLink>; Department of Dermatology and Venereology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Tsoi+LC%22">Tsoi LC</searchLink>; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Uebe+S%22">Uebe S</searchLink>; Institute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Watts+K%22">Watts K</searchLink>; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Barker+JN%22">Barker JN</searchLink>; 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Department of Dermatology, Clinic of Orthopedy, Rheumatology and Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Paternoster+L%22">Paternoster L</searchLink>; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Dand+N%22">Dand N</searchLink>; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, SE1 9RT, UK.<br /><searchLink fieldCode="AU" term="%22Smith+CH%22">Smith CH</searchLink>; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Simpson+MA%22">Simpson MA</searchLink>; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, SE1 9RT, UK. michael.simpson@kcl.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101475844%22">Genome medicine</searchLink> [Genome Med] 2025 Dec 17; Vol. 18 (1), pp. 14. <i>Date of Electronic Publication: </i>2025 Dec 17.
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          Name:
            NameFull: Uebe S
      – PersonEntity:
          Name:
            NameFull: Watts K
      – PersonEntity:
          Name:
            NameFull: Barker JN
      – PersonEntity:
          Name:
            NameFull: Mahil SK
      – PersonEntity:
          Name:
            NameFull: Langan SM
      – PersonEntity:
          Name:
            NameFull: Brown SJ
      – PersonEntity:
          Name:
            NameFull: Løset M
      – PersonEntity:
          Name:
            NameFull: Paternoster L
      – PersonEntity:
          Name:
            NameFull: Dand N
      – PersonEntity:
          Name:
            NameFull: Smith CH
      – PersonEntity:
          Name:
            NameFull: Simpson MA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 17
              M: 12
              Text: 2025 Dec 17
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1756-994X
          Numbering:
            – Type: volume
              Value: 18
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Genome medicine
              Type: main
ResultId 1