Endogenous Osteocyte-Osteoclast Signaling Enables Growth Factor-Free Bone Remodeling, Drug Response, and Cancer Invasion in a Nanoscale Calcified Bone-on-a-Chip Model.
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| Title: | Endogenous Osteocyte-Osteoclast Signaling Enables Growth Factor-Free Bone Remodeling, Drug Response, and Cancer Invasion in a Nanoscale Calcified Bone-on-a-Chip Model. |
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| Authors: | Sousa MGC; Knight Cancer Precision Biofabrication Hub, Cancer Early Detection Advanced Research (CEDAR), Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.; Department of Oral Rehabilitation and Biosciences, School of Dentistry, Oregon Health & Science University, Portland, Oregon, USA., Athirasala A; Knight Cancer Precision Biofabrication Hub, Cancer Early Detection Advanced Research (CEDAR), Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.; Department of Oral Rehabilitation and Biosciences, School of Dentistry, Oregon Health & Science University, Portland, Oregon, USA., Roth DM; Knight Cancer Precision Biofabrication Hub, Cancer Early Detection Advanced Research (CEDAR), Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.; Department of Oral Rehabilitation and Biosciences, School of Dentistry, Oregon Health & Science University, Portland, Oregon, USA., Fraga MAA; Department of Restorative Dentistry, Faculdade de Odontologia de Piracicaba (FOP), Universidade Estadual de Campinas, Piracicaba, São Paulo, Brazil., Vignolo SM; Knight Cancer Precision Biofabrication Hub, Cancer Early Detection Advanced Research (CEDAR), Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.; Division of Oncological Sciences, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA., Doe A; Cancer Early Detection Advanced Research (CEDAR), Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA., Lee J; Precision oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA., Romanowicz GE; Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, Oregon, USA., Nguyen JV; Department of Oral Rehabilitation and Biosciences, School of Dentistry, Oregon Health & Science University, Portland, Oregon, USA., Lin ASP; Department of Restorative Dentistry, Faculdade de Odontologia de Piracicaba (FOP), Universidade Estadual de Campinas, Piracicaba, São Paulo, Brazil., Franca CM; Knight Cancer Precision Biofabrication Hub, Cancer Early Detection Advanced Research (CEDAR), Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.; Department of Oral Rehabilitation and Biosciences, School of Dentistry, Oregon Health & Science University, Portland, Oregon, USA., Guldberg RE; Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, Oregon, USA., Bertassoni LE; Knight Cancer Precision Biofabrication Hub, Cancer Early Detection Advanced Research (CEDAR), Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.; Division of Oncological Sciences, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.; Center for Regenerative Medicine, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.; Department of Oral Rehabilitation and Biosciences, School of Dentistry, Oregon Health & Science University, Portland, Oregon, USA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2025 Dec 11. Date of Electronic Publication: 2025 Dec 11. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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