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Deprivation of EGFR signal causes senolysis in PDAC with CDK4/6 inhibition.

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Title: Deprivation of EGFR signal causes senolysis in PDAC with CDK4/6 inhibition.
Authors: Zhang Y; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan., Kohno S; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan., Gao K; Division of Cancer and Senescence Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan., Hasan M; Division of Animal Disease Model, Research Center for Experimental Modeling of Human Disease, Kanazawa University, Kanazawa, Ishikawa, Japan.; Department of Public Health, Daffodil International University, Dhaka, Bangladesh., Baba T; Division of Cancer and Senescence Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan., Zhang Z; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.; Division of Cancer and Senescence Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan., Sankoda N; Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Yu H; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan., Pan J; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan., Gotoh N; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan., Nakanishi M; Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan., Yamada Y; Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Sheng J; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.; Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.; Department of Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Daikoku T; Division of Animal Disease Model, Research Center for Experimental Modeling of Human Disease, Kanazawa University, Kanazawa, Ishikawa, Japan., Johmura Y; Division of Cancer and Senescence Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan., Takahashi C; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan. chtakaha@staff.kanazawa-u.ac.jp.
Source: Cell death and differentiation [Cell Death Differ] 2026 Jun; Vol. 33 (6), pp. 1218-1233. Date of Electronic Publication: 2025 Dec 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
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  Data: Deprivation of EGFR signal causes senolysis in PDAC with CDK4/6 inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.<br /><searchLink fieldCode="AU" term="%22Kohno+S%22">Kohno S</searchLink>; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.<br /><searchLink fieldCode="AU" term="%22Gao+K%22">Gao K</searchLink>; Division of Cancer and Senescence Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.<br /><searchLink fieldCode="AU" term="%22Hasan+M%22">Hasan M</searchLink>; Division of Animal Disease Model, Research Center for Experimental Modeling of Human Disease, Kanazawa University, Kanazawa, Ishikawa, Japan.; Department of Public Health, Daffodil International University, Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Baba+T%22">Baba T</searchLink>; Division of Cancer and Senescence Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.; Division of Cancer and Senescence Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.<br /><searchLink fieldCode="AU" term="%22Sankoda+N%22">Sankoda N</searchLink>; Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.<br /><searchLink fieldCode="AU" term="%22Pan+J%22">Pan J</searchLink>; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.<br /><searchLink fieldCode="AU" term="%22Gotoh+N%22">Gotoh N</searchLink>; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.<br /><searchLink fieldCode="AU" term="%22Nakanishi+M%22">Nakanishi M</searchLink>; Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamada+Y%22">Yamada Y</searchLink>; Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sheng+J%22">Sheng J</searchLink>; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.; Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.; Department of Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Daikoku+T%22">Daikoku T</searchLink>; Division of Animal Disease Model, Research Center for Experimental Modeling of Human Disease, Kanazawa University, Kanazawa, Ishikawa, Japan.<br /><searchLink fieldCode="AU" term="%22Johmura+Y%22">Johmura Y</searchLink>; Division of Cancer and Senescence Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+C%22">Takahashi C</searchLink>; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan. chtakaha@staff.kanazawa-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%229437445%22">Cell death and differentiation</searchLink> [Cell Death Differ] 2026 Jun; Vol. 33 (6), pp. 1218-1233. <i>Date of Electronic Publication: </i>2025 Dec 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9437445 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5403 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213509047%22">13509047 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Differ <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41418-025-01634-0
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      – TitleFull: Deprivation of EGFR signal causes senolysis in PDAC with CDK4/6 inhibition.
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              Text: 2026 Jun
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