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Targeting the tumor cell-intrinsic ITGB2 axis inhibits melanoma progression.

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Title: Targeting the tumor cell-intrinsic ITGB2 axis inhibits melanoma progression.
Authors: Rasbach E; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of General and Visceral Surgery, Ulm University Medical Center, Ulm, 89081, Germany., Migayron L; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Brandenburg A; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Center for Skin Diseases, Clinic for Dermatooncology and Phlebology, University Hospital Bonn, Bonn, 53127, Germany., Singh P; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Martins C; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Kassem A; Department of General and Visceral Surgery, Ulm University Medical Center, Ulm, 89081, Germany., Karkempetzaki AI; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Suessner N; Department of General and Visceral Surgery, Ulm University Medical Center, Ulm, 89081, Germany., Kulcsar Z; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Center for Skin Diseases, Clinic for Dermatooncology and Phlebology, University Hospital Bonn, Bonn, 53127, Germany., Riopedre J; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Silva M; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Zhen E; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Xu S; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Mucciarone K; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Holzgruber J; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of Dermatology and Venerology, Johannes Kepler University, Linz, 4020, Austria., Williams JB; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Birgin E; Department of General and Visceral Surgery, Ulm University Medical Center, Ulm, 89081, Germany., Levesque MP; Department of Dermatology, University of Zurich Hospital, University of Zurich, Schlieren, Switzerland., Martínez-Gómez JM; Department of Dermatology, University of Zurich Hospital, University of Zurich, Schlieren, Switzerland., Dummer R; Department of Dermatology, University of Zurich Hospital, University of Zurich, Schlieren, Switzerland., Landsberg J; Center for Skin Diseases, Clinic for Dermatooncology and Phlebology, University Hospital Bonn, Bonn, 53127, Germany., Lian CG; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Murphy GF; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Berdan EL; Department of Biostatistics, Harvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Harvard Medical School, Boston, MA, 02115, USA., Sui SH; Department of Biostatistics, Harvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Harvard Medical School, Boston, MA, 02115, USA., Kupper TS; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Rahbari NN; Department of General and Visceral Surgery, Ulm University Medical Center, Ulm, 89081, Germany., Lee N; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; The Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, NY, 10016, New York, USA., Barthel SR; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. sbarthel@bwh.harvard.edu.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. sbarthel@bwh.harvard.edu., Schatton T; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. tschatton@bwh.harvard.edu.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. tschatton@bwh.harvard.edu.; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA. tschatton@bwh.harvard.edu.
Source: Molecular cancer [Mol Cancer] 2025 Dec 18; Vol. 24 (1), pp. 310. Date of Electronic Publication: 2025 Dec 18.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting the tumor cell-intrinsic ITGB2 axis inhibits melanoma progression.
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  Data: <searchLink fieldCode="AU" term="%22Rasbach+E%22">Rasbach E</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of General and Visceral Surgery, Ulm University Medical Center, Ulm, 89081, Germany.<br /><searchLink fieldCode="AU" term="%22Migayron+L%22">Migayron L</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Brandenburg+A%22">Brandenburg A</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Center for Skin Diseases, Clinic for Dermatooncology and Phlebology, University Hospital Bonn, Bonn, 53127, Germany.<br /><searchLink fieldCode="AU" term="%22Singh+P%22">Singh P</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Martins+C%22">Martins C</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Kassem+A%22">Kassem A</searchLink>; Department of General and Visceral Surgery, Ulm University Medical Center, Ulm, 89081, Germany.<br /><searchLink fieldCode="AU" term="%22Karkempetzaki+AI%22">Karkempetzaki AI</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Suessner+N%22">Suessner N</searchLink>; Department of General and Visceral Surgery, Ulm University Medical Center, Ulm, 89081, Germany.<br /><searchLink fieldCode="AU" term="%22Kulcsar+Z%22">Kulcsar Z</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Center for Skin Diseases, Clinic for Dermatooncology and Phlebology, University Hospital Bonn, Bonn, 53127, Germany.<br /><searchLink fieldCode="AU" term="%22Riopedre+J%22">Riopedre J</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Silva+M%22">Silva M</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Zhen+E%22">Zhen E</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Mucciarone+K%22">Mucciarone K</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Holzgruber+J%22">Holzgruber J</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of Dermatology and Venerology, Johannes Kepler University, Linz, 4020, Austria.<br /><searchLink fieldCode="AU" term="%22Williams+JB%22">Williams JB</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Birgin+E%22">Birgin E</searchLink>; Department of General and Visceral Surgery, Ulm University Medical Center, Ulm, 89081, Germany.<br /><searchLink fieldCode="AU" term="%22Levesque+MP%22">Levesque MP</searchLink>; Department of Dermatology, University of Zurich Hospital, University of Zurich, Schlieren, Switzerland.<br /><searchLink fieldCode="AU" term="%22Martínez-Gómez+JM%22">Martínez-Gómez JM</searchLink>; Department of Dermatology, University of Zurich Hospital, University of Zurich, Schlieren, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dummer+R%22">Dummer R</searchLink>; Department of Dermatology, University of Zurich Hospital, University of Zurich, Schlieren, Switzerland.<br /><searchLink fieldCode="AU" term="%22Landsberg+J%22">Landsberg J</searchLink>; Center for Skin Diseases, Clinic for Dermatooncology and Phlebology, University Hospital Bonn, Bonn, 53127, Germany.<br /><searchLink fieldCode="AU" term="%22Lian+CG%22">Lian CG</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Murphy+GF%22">Murphy GF</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Berdan+EL%22">Berdan EL</searchLink>; Department of Biostatistics, Harvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Sui+SH%22">Sui SH</searchLink>; Department of Biostatistics, Harvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Kupper+TS%22">Kupper TS</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Rahbari+NN%22">Rahbari NN</searchLink>; Department of General and Visceral Surgery, Ulm University Medical Center, Ulm, 89081, Germany.<br /><searchLink fieldCode="AU" term="%22Lee+N%22">Lee N</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; The Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, NY, 10016, New York, USA.<br /><searchLink fieldCode="AU" term="%22Barthel+SR%22">Barthel SR</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. sbarthel@bwh.harvard.edu.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. sbarthel@bwh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Schatton+T%22">Schatton T</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. tschatton@bwh.harvard.edu.; Program of Glyco-Immunology and Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. tschatton@bwh.harvard.edu.; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA. tschatton@bwh.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101147698%22">Molecular cancer</searchLink> [Mol Cancer] 2025 Dec 18; Vol. 24 (1), pp. 310. <i>Date of Electronic Publication: </i>2025 Dec 18.
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