High-throughput in silico screen uncovers key regulators of 3D genome architecture.
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| Title: | High-throughput in silico screen uncovers key regulators of 3D genome architecture. |
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| Authors: | Bai J; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lyu Q; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Tan J; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.; Department of Medicine and Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY, USA., Issner R; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA., Tischer B; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA., Liu H; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.; Society of Fellows, Harvard University, Cambridge, MA, USA., Goel V; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Biological Engineering and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ling X; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA., Bernstein BE; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Cancer Biology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Tsirigos A; Department of Medicine and Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY, USA., Hansen AS; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Biological Engineering and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Xia B; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.; Society of Fellows, Harvard University, Cambridge, MA, USA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2025 Dec 11. Date of Electronic Publication: 2025 Dec 11. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41415375 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: High-throughput in silico screen uncovers key regulators of 3D genome architecture. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Bai+J%22">Bai J</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lyu+Q%22">Lyu Q</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tan+J%22">Tan J</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.; Department of Medicine and Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Issner+R%22">Issner R</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Tischer+B%22">Tischer B</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.; Society of Fellows, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Goel+V%22">Goel V</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Biological Engineering and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Ling+X%22">Ling X</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bernstein+BE%22">Bernstein BE</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Cancer Biology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tsirigos+A%22">Tsirigos A</searchLink>; Department of Medicine and Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hansen+AS%22">Hansen AS</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Biological Engineering and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Xia+B%22">Xia B</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.; Society of Fellows, Harvard University, Cambridge, MA, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Dec 11. <i>Date of Electronic Publication: </i>2025 Dec 11. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Preprint – Name: TitleSource Label: Journal Info Group: Src Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41415375 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.64898/2025.12.09.693120 Languages: – Code: eng Text: English Titles: – TitleFull: High-throughput in silico screen uncovers key regulators of 3D genome architecture. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bai J – PersonEntity: Name: NameFull: Lyu Q – PersonEntity: Name: NameFull: Tan J – PersonEntity: Name: NameFull: Issner R – PersonEntity: Name: NameFull: Tischer B – PersonEntity: Name: NameFull: Liu H – PersonEntity: Name: NameFull: Goel V – PersonEntity: Name: NameFull: Ling X – PersonEntity: Name: NameFull: Bernstein BE – PersonEntity: Name: NameFull: Tsirigos A – PersonEntity: Name: NameFull: Hansen AS – PersonEntity: Name: NameFull: Xia B IsPartOfRelationships: – BibEntity: Dates: – D: 11 M: 12 Text: 2025 Dec 11 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2692-8205 Titles: – TitleFull: BioRxiv : the preprint server for biology Type: main |
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