High-throughput in silico screen uncovers key regulators of 3D genome architecture.

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Title: High-throughput in silico screen uncovers key regulators of 3D genome architecture.
Authors: Bai J; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lyu Q; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Tan J; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.; Department of Medicine and Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY, USA., Issner R; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA., Tischer B; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA., Liu H; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.; Society of Fellows, Harvard University, Cambridge, MA, USA., Goel V; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Biological Engineering and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ling X; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA., Bernstein BE; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Cancer Biology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Tsirigos A; Department of Medicine and Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY, USA., Hansen AS; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Biological Engineering and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Xia B; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.; Society of Fellows, Harvard University, Cambridge, MA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Dec 11. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41415375
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PubType: Academic Journal
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  Data: <searchLink fieldCode="AU" term="%22Bai+J%22">Bai J</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lyu+Q%22">Lyu Q</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tan+J%22">Tan J</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.; Department of Medicine and Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Issner+R%22">Issner R</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Tischer+B%22">Tischer B</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.; Society of Fellows, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Goel+V%22">Goel V</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Biological Engineering and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Ling+X%22">Ling X</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bernstein+BE%22">Bernstein BE</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Cancer Biology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tsirigos+A%22">Tsirigos A</searchLink>; Department of Medicine and Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hansen+AS%22">Hansen AS</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Biological Engineering and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Xia+B%22">Xia B</searchLink>; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.; Society of Fellows, Harvard University, Cambridge, MA, USA.
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              Text: 2025 Dec 11
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