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Molecular and clinical insights of trastuzumab deruxtecan efficacy in advanced breast cancer.

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Title: Molecular and clinical insights of trastuzumab deruxtecan efficacy in advanced breast cancer.
Authors: Nassar AH; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States.; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States., Bou Farhat E; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States., Abushukair H; Division of Medical Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.; Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States., Alchoueriy M; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States., Salem S; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States., Machaalani M; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Adib E; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States., Henske EP; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States., Babu P; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States., Choueiri TK; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Rakaee M; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Department of Cancer Genetics, Oslo University Hospital, Oslo, Norway., Busund LR; Department of Clinical Pathology, University Hospital of North-Norway, Tromso, Norway., Takabe Y; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States., Lau SF; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States., Rall K; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States., Naqash AR; Division of Medical Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.; Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States., Jansen C; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States., Wang X; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States., Challa P; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States., Tarantino P; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Partridge AH; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Tolaney SM; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Kwiatkowski DJ; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Winer EP; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States.
Source: Journal of the National Cancer Institute [J Natl Cancer Inst] 2026 Apr 01; Vol. 118 (4), pp. 669-679.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 7503089 Publication Model: Print Cited Medium: Internet ISSN: 1460-2105 (Electronic) Linking ISSN: 00278874 NLM ISO Abbreviation: J Natl Cancer Inst Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Nassar+AH%22">Nassar AH</searchLink>; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States.; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Bou+Farhat+E%22">Bou Farhat E</searchLink>; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Abushukair+H%22">Abushukair H</searchLink>; Division of Medical Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.; Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.<br /><searchLink fieldCode="AU" term="%22Alchoueriy+M%22">Alchoueriy M</searchLink>; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Salem+S%22">Salem S</searchLink>; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Machaalani+M%22">Machaalani M</searchLink>; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Adib+E%22">Adib E</searchLink>; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Henske+EP%22">Henske EP</searchLink>; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Babu+P%22">Babu P</searchLink>; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States.<br /><searchLink fieldCode="AU" term="%22Choueiri+TK%22">Choueiri TK</searchLink>; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Rakaee+M%22">Rakaee M</searchLink>; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Department of Cancer Genetics, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Busund+LR%22">Busund LR</searchLink>; Department of Clinical Pathology, University Hospital of North-Norway, Tromso, Norway.<br /><searchLink fieldCode="AU" term="%22Takabe+Y%22">Takabe Y</searchLink>; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States.<br /><searchLink fieldCode="AU" term="%22Lau+SF%22">Lau SF</searchLink>; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States.<br /><searchLink fieldCode="AU" term="%22Rall+K%22">Rall K</searchLink>; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States.<br /><searchLink fieldCode="AU" term="%22Naqash+AR%22">Naqash AR</searchLink>; Division of Medical Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.; Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.<br /><searchLink fieldCode="AU" term="%22Jansen+C%22">Jansen C</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States.<br /><searchLink fieldCode="AU" term="%22Challa+P%22">Challa P</searchLink>; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States.<br /><searchLink fieldCode="AU" term="%22Tarantino+P%22">Tarantino P</searchLink>; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Partridge+AH%22">Partridge AH</searchLink>; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Tolaney+SM%22">Tolaney SM</searchLink>; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Kwiatkowski+DJ%22">Kwiatkowski DJ</searchLink>; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Winer+EP%22">Winer EP</searchLink>; Division of Medical Oncology, Yale Cancer Center, New Haven, CT, United States.
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