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Diabetes increases SCO-spondin secretion but reduces Wnt5a interaction with ependymal cells, inducing ciliary stiffness and Frizzled-2 downregulation.

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Title: Diabetes increases SCO-spondin secretion but reduces Wnt5a interaction with ependymal cells, inducing ciliary stiffness and Frizzled-2 downregulation.
Authors: Cifuentes M; Department of Cell Biology, Genetics and Physiology, University of Malaga, Malaga, Spain., Ramírez E; Laboratory of Neurobiology and Stem Cells, NeuroCellT, Department of Cellular Biology, Faculty of Biological Sciences, University of Concepción, Concepción, Chile., Barahona MJ; Laboratory of Neurobiology and Stem Cells, NeuroCellT, Department of Cellular Biology, Faculty of Biological Sciences, University of Concepción, Concepción, Chile; Facultad de Ciencias, Universidad San Sebastián, Concepción, Chile., Martínez F; Laboratory of Neurobiology and Stem Cells, NeuroCellT, Department of Cellular Biology, Faculty of Biological Sciences, University of Concepción, Concepción, Chile., de Lima I; Laboratory of Neurobiology and Stem Cells, NeuroCellT, Department of Cellular Biology, Faculty of Biological Sciences, University of Concepción, Concepción, Chile., Ferrada L; Center for Advanced Microscopy CMA BIO BIO, University of Concepción, Concepción, Chile., Bertinat R; Laboratory of Neurobiology and Stem Cells, NeuroCellT, Department of Cellular Biology, Faculty of Biological Sciences, University of Concepción, Concepción, Chile., Ávila F; Universidad de Talca, Talca, Chile., Saldivia N; Laboratory of Neurobiology and Stem Cells, NeuroCellT, Department of Cellular Biology, Faculty of Biological Sciences, University of Concepción, Concepción, Chile., Pérez-Martín M; Department of Cell Biology, Genetics and Physiology, University of Malaga, Malaga, Spain; Biomedical Research Institute of Malaga and Nanomedicine Platform-IBIMA, Bionand Platform, 29590 Malaga, Spain., Oliver-Martin B; Biomedical Research Institute of Malaga and Nanomedicine Platform-IBIMA, Bionand Platform, 29590 Malaga, Spain; Regional University Hospital of Malaga, Malaga, Spain., Ciano-Petersen N; Biomedical Research Institute of Malaga and Nanomedicine Platform-IBIMA, Bionand Platform, 29590 Malaga, Spain; Regional University Hospital of Malaga, Malaga, Spain., Fernández-Arjona MDM; Biomedical Research Institute of Malaga and Nanomedicine Platform-IBIMA, Bionand Platform, 29590 Malaga, Spain; Regional University Hospital of Malaga, Malaga, Spain., Salazar K; Laboratory of Neurobiology and Stem Cells, NeuroCellT, Department of Cellular Biology, Faculty of Biological Sciences, University of Concepción, Concepción, Chile; Center for Advanced Microscopy CMA BIO BIO, University of Concepción, Concepción, Chile. Electronic address: katterinsalazar@udec.cl., Nualart F; Laboratory of Neurobiology and Stem Cells, NeuroCellT, Department of Cellular Biology, Faculty of Biological Sciences, University of Concepción, Concepción, Chile; Center for Advanced Microscopy CMA BIO BIO, University of Concepción, Concepción, Chile. Electronic address: frnualart@udec.cl.
Source: Neurobiology of disease [Neurobiol Dis] 2026 Jan; Vol. 218, pp. 107225. Date of Electronic Publication: 2025 Dec 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1095-953X
DOI:10.1016/j.nbd.2025.107225