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Thrombopoietin increases susceptibility for EVI1 + KMT2A-MLLT3-driven AML expressing stem cell genes linked to poor outcome.

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Title: Thrombopoietin increases susceptibility for EVI1 + KMT2A-MLLT3-driven AML expressing stem cell genes linked to poor outcome.
Authors: Châtel-Soulet HÉ; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland., Juge S; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland., Pereira AL; Department of Medical Oncology and Haematology, University Hospital Zürich, Zürich, Switzerland., Seguin J; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland.; Swiss Institute of Bioinformatics (SIB), Basel, Switzerland., El Taher A; Swiss Institute of Bioinformatics (SIB), Basel, Switzerland.; Bioinformatics Core Facility, University of Basel, Basel, Switzerland., Valigi F; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland., Jevtic Z; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland., Sivalingam R; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland., Bagger FO; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland.; Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Büschl P; Department of Medical Oncology and Haematology, University Hospital Zürich, Zürich, Switzerland., Almosailleakh M; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland.; Biotech Research and Innovation Center (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Tzankov A; Institute for Pathology, University of Basel, Basel, Switzerland., Tong W; Division of Haematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Kurokawa M; Department of Haematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Nombela Arrieta C; Department of Medical Oncology and Haematology, University Hospital Zürich, Zürich, Switzerland., Schwaller J; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland. J.Schwaller@unibas.ch.
Source: Nature communications [Nat Commun] 2025 Dec 19; Vol. 17 (1), pp. 892. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Thrombopoietin increases susceptibility for EVI1 + KMT2A-MLLT3-driven AML expressing stem cell genes linked to poor outcome.
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  Data: <searchLink fieldCode="AU" term="%22Châtel-Soulet+HÉ%22">Châtel-Soulet HÉ</searchLink>; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Juge+S%22">Juge S</searchLink>; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pereira+AL%22">Pereira AL</searchLink>; Department of Medical Oncology and Haematology, University Hospital Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Seguin+J%22">Seguin J</searchLink>; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland.; Swiss Institute of Bioinformatics (SIB), Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22El+Taher+A%22">El Taher A</searchLink>; Swiss Institute of Bioinformatics (SIB), Basel, Switzerland.; Bioinformatics Core Facility, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Valigi+F%22">Valigi F</searchLink>; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jevtic+Z%22">Jevtic Z</searchLink>; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sivalingam+R%22">Sivalingam R</searchLink>; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bagger+FO%22">Bagger FO</searchLink>; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland.; Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Büschl+P%22">Büschl P</searchLink>; Department of Medical Oncology and Haematology, University Hospital Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Almosailleakh+M%22">Almosailleakh M</searchLink>; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland.; Biotech Research and Innovation Center (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Tzankov+A%22">Tzankov A</searchLink>; Institute for Pathology, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tong+W%22">Tong W</searchLink>; Division of Haematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kurokawa+M%22">Kurokawa M</searchLink>; Department of Haematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nombela+Arrieta+C%22">Nombela Arrieta C</searchLink>; Department of Medical Oncology and Haematology, University Hospital Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schwaller+J%22">Schwaller J</searchLink>; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland. J.Schwaller@unibas.ch.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Dec 19; Vol. 17 (1), pp. 892. <i>Date of Electronic Publication: </i>2025 Dec 19.
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