Efficacy of tirzepatide versus semaglutide in achieving therapeutic targets in type 2 diabetes: a post hoc analysis of the SURPASS-2 Trial.

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Title: Efficacy of tirzepatide versus semaglutide in achieving therapeutic targets in type 2 diabetes: a post hoc analysis of the SURPASS-2 Trial.
Authors: Neves JS; RISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal. jsneves@med.up.pt.; Department of Endocrinology, Diabetes and Metabolism, ULS São João, Porto, Portugal. jsneves@med.up.pt., Leite AR; RISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.; Department of Endocrinology, Diabetes and Metabolism, ULS São João, Porto, Portugal., Vale C; RISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.; Department of Internal Medicine, ULS São João, Porto, Portugal., Marques P; RISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.; Department of Internal Medicine, ULS São João, Porto, Portugal., Vasques-Nóvoa F; RISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.; Department of Internal Medicine, ULS São João, Porto, Portugal., Leite-Moreira A; RISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.; Department of Cardiothoracic Surgery, ULS São João, Porto, Portugal., Ferreira JP; RISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.; Université de Lorraine, Inserm, Centre d'Investigations Cliniques - Plurithématique 14-33, Nancy, France.; Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.
Source: Diabetologia [Diabetologia] 2026 May; Vol. 69 (5), pp. 1216-1225. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0428
DOI:10.1007/s00125-025-06637-7