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Recombination junctions from antibody isotype switching classify immune and DNA repair dysfunction.

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Title: Recombination junctions from antibody isotype switching classify immune and DNA repair dysfunction.
Authors: Vázquez García C; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Obermayer B; Core Unit Bioinformatics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Keller B; Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Lebedin M; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Ratswohl C; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Abolhassani H; Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children´s Medical Center, Tehran University of Medical Sciences, Tehran, Iran., Busse A; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), partner site Berlin, a partnership between German Cancer Research Center (DKFZ) and Charité - Universitätsmedizin Berlin, Berlin, Germany., Di Virgilio M; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Mathas S; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a junction cooperation between Charité and MDC, Berlin, Germany., Speiser D; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Gynecology with Breast Center, Hereditary Breast and Ovarian Cancer Center, Charité - Universitätsmedizin Berlin, Berlin, Germany., Beule D; Core Unit Bioinformatics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Pan-Hammarström Q; Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Warnatz K; Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., de la Rosa K; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany. Kathrin.delaRosa@helmholtz-hzi.de.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany. Kathrin.delaRosa@helmholtz-hzi.de.; Centre for Individualised Infection Medicine (CiiM), Hannover Medical School (MHH), Hannover, Germany. Kathrin.delaRosa@helmholtz-hzi.de.; Department of Personalized Immunotherapy, Centre for Individualized Infection Medicine (CiiM), Helmholtz Centre for Infection Research (HZI), Hannover, Germany. Kathrin.delaRosa@helmholtz-hzi.de.
Source: Nature communications [Nat Commun] 2025 Dec 19; Vol. 16 (1), pp. 11331. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Vázquez+García+C%22">Vázquez García C</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Obermayer+B%22">Obermayer B</searchLink>; Core Unit Bioinformatics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Keller+B%22">Keller B</searchLink>; Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lebedin+M%22">Lebedin M</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ratswohl+C%22">Ratswohl C</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Abolhassani+H%22">Abolhassani H</searchLink>; Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children´s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Busse+A%22">Busse A</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), partner site Berlin, a partnership between German Cancer Research Center (DKFZ) and Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Di+Virgilio+M%22">Di Virgilio M</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mathas+S%22">Mathas S</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a junction cooperation between Charité and MDC, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Speiser+D%22">Speiser D</searchLink>; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Gynecology with Breast Center, Hereditary Breast and Ovarian Cancer Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Beule+D%22">Beule D</searchLink>; Core Unit Bioinformatics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Pan-Hammarström+Q%22">Pan-Hammarström Q</searchLink>; Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Warnatz+K%22">Warnatz K</searchLink>; Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22de+la+Rosa+K%22">de la Rosa K</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany. Kathrin.delaRosa@helmholtz-hzi.de.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany. Kathrin.delaRosa@helmholtz-hzi.de.; Centre for Individualised Infection Medicine (CiiM), Hannover Medical School (MHH), Hannover, Germany. Kathrin.delaRosa@helmholtz-hzi.de.; Department of Personalized Immunotherapy, Centre for Individualized Infection Medicine (CiiM), Helmholtz Centre for Infection Research (HZI), Hannover, Germany. Kathrin.delaRosa@helmholtz-hzi.de.
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