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ZAR1 pathogenic variants disrupt maternal mRNA storage and cause oocyte maturation defects in humans.

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Title: ZAR1 pathogenic variants disrupt maternal mRNA storage and cause oocyte maturation defects in humans.
Authors: Liao XQ; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China.; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.; Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China., Zhao S; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China.; Department of Obstetrics and Gynecology, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, 250022, China., Zhang CL; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, 250012, China., Zhu Y; Medical Experimental Center, Guangdong Second Provincial General Hospital, Guangzhou, China., Wen J; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China., Wang Y; MOE Key Laboratory for Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences Institute Zhejiang University, Hangzhou, China., Liu SY; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China.; Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China., Su W; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China., Zhang JT; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China., Lu QW; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China., Gong F; Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China., Lin G; Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China., Fan HY; MOE Key Laboratory for Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences Institute Zhejiang University, Hangzhou, China. hyfan@zju.edu.cn., Zheng W; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China. ustczw@163.com.; Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China. ustczw@163.com., Zhao H; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China. hanzh80@sdu.edu.cn.; Department of Obstetrics and Gynecology, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, 250022, China. hanzh80@sdu.edu.cn.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, 250012, China. hanzh80@sdu.edu.cn., Sha QQ; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China. shaqianqian@zju.edu.cn.; Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China. shaqianqian@zju.edu.cn.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2025 Dec 20; Vol. 83 (1), pp. 37. Date of Electronic Publication: 2025 Dec 20.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ZAR1 pathogenic variants disrupt maternal mRNA storage and cause oocyte maturation defects in humans.
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  Data: <searchLink fieldCode="AU" term="%22Liao+XQ%22">Liao XQ</searchLink>; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China.; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.; Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhao+S%22">Zhao S</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China.; Department of Obstetrics and Gynecology, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, 250022, China.<br /><searchLink fieldCode="AU" term="%22Zhang+CL%22">Zhang CL</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Medical Experimental Center, Guangdong Second Provincial General Hospital, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wen+J%22">Wen J</searchLink>; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; MOE Key Laboratory for Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences Institute Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+SY%22">Liu SY</searchLink>; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China.; Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Su+W%22">Su W</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Zhang+JT%22">Zhang JT</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Lu+QW%22">Lu QW</searchLink>; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Gong+F%22">Gong F</searchLink>; Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Lin+G%22">Lin G</searchLink>; Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Fan+HY%22">Fan HY</searchLink>; MOE Key Laboratory for Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences Institute Zhejiang University, Hangzhou, China. hyfan@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zheng+W%22">Zheng W</searchLink>; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China. ustczw@163.com.; Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China. ustczw@163.com.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China. hanzh80@sdu.edu.cn.; Department of Obstetrics and Gynecology, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, 250022, China. hanzh80@sdu.edu.cn.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, 250012, China. hanzh80@sdu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Sha+QQ%22">Sha QQ</searchLink>; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China. shaqianqian@zju.edu.cn.; Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China. shaqianqian@zju.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229705402%22">Cellular and molecular life sciences : CMLS</searchLink> [Cell Mol Life Sci] 2025 Dec 20; Vol. 83 (1), pp. 37. <i>Date of Electronic Publication: </i>2025 Dec 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9705402 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1420-9071 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221420682X%22">1420682X </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Life Sci <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00018-025-06000-4
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              Text: 2025 Dec 20
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