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Pumpkin seed oil improves hepatotoxicity in rats through inhibition of CYP2E1 and activation of Nrf2 signaling pathways.

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Title: Pumpkin seed oil improves hepatotoxicity in rats through inhibition of CYP2E1 and activation of Nrf2 signaling pathways.
Authors: Esmail NW; Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Egypt., El-Sheikh SM; Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Egypt., Korany RMS; Pathology Department, Faculty of Veterinary Medicine, Cairo University, Egypt., Hassan AA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, El Saleheya El Gadida University, El Saleheya El Gadida, 44813, Egypt., Baraka SM; Chemistry of Natural Compounds Department, National Research Centre, Giza 12622, Egypt., Alharbi HM; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. Electronic address: Hmalharbi@pnu.edu.sa., Ismail AK; Department of Forensic Medicine and Toxicology, College of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt; Department of clinical pharmacology and forensic medicine and toxicology, College of Medicine, Taif University, Saudi Arabia., Mansour DA; Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, University of Sadat City, Egypt., Mahboub HH; Department of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, P.O. Box 44511, Zagazig, Sharkia, Egypt. Electronic address: hhhmb@yahoo.com., Fahmy EM; Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Egypt.
Source: Tissue & cell [Tissue Cell] 2026 Apr; Vol. 99, pp. 103286. Date of Electronic Publication: 2025 Dec 17.
Publication Type: Journal Article
Journal Info: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pumpkin seed oil improves hepatotoxicity in rats through inhibition of CYP2E1 and activation of Nrf2 signaling pathways.
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  Data: <searchLink fieldCode="AU" term="%22Esmail+NW%22">Esmail NW</searchLink>; Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Sheikh+SM%22">El-Sheikh SM</searchLink>; Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Egypt.<br /><searchLink fieldCode="AU" term="%22Korany+RMS%22">Korany RMS</searchLink>; Pathology Department, Faculty of Veterinary Medicine, Cairo University, Egypt.<br /><searchLink fieldCode="AU" term="%22Hassan+AA%22">Hassan AA</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, El Saleheya El Gadida University, El Saleheya El Gadida, 44813, Egypt.<br /><searchLink fieldCode="AU" term="%22Baraka+SM%22">Baraka SM</searchLink>; Chemistry of Natural Compounds Department, National Research Centre, Giza 12622, Egypt.<br /><searchLink fieldCode="AU" term="%22Alharbi+HM%22">Alharbi HM</searchLink>; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. Electronic address: Hmalharbi@pnu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Ismail+AK%22">Ismail AK</searchLink>; Department of Forensic Medicine and Toxicology, College of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt; Department of clinical pharmacology and forensic medicine and toxicology, College of Medicine, Taif University, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Mansour+DA%22">Mansour DA</searchLink>; Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, University of Sadat City, Egypt.<br /><searchLink fieldCode="AU" term="%22Mahboub+HH%22">Mahboub HH</searchLink>; Department of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, P.O. Box 44511, Zagazig, Sharkia, Egypt. Electronic address: hhhmb@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Fahmy+EM%22">Fahmy EM</searchLink>; Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Egypt.
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  Data: <searchLink fieldCode="JN" term="%220214745%22">Tissue & cell</searchLink> [Tissue Cell] 2026 Apr; Vol. 99, pp. 103286. <i>Date of Electronic Publication: </i>2025 Dec 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Churchill+Livingstone%22">Churchill Livingstone </searchLink><i>Country of Publication: </i>Scotland <i>NLM ID: </i>0214745 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-3072 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200408166%22">00408166 </searchLink><i>NLM ISO Abbreviation: </i>Tissue Cell <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.tice.2025.103286
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        Text: English
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        StartPage: 103286
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              Text: 2026 Apr
              Type: published
              Y: 2026
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