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Sequential sample size calculations and learning curves safeguard the robust development of a clinical prediction model for individuals.

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Title: Sequential sample size calculations and learning curves safeguard the robust development of a clinical prediction model for individuals.
Authors: Legha A; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom. Electronic address: a.legha@bham.ac.uk., Ensor J; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom., Whittle R; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom., Archer L; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom; Institute of Data and AI, University of Birmingham, Birmingham, United Kingdom., Van Calster B; Leuven Unit for Health Technology Assessment Research (LUHTAR), KU Leuven, Leuven, Belgium; Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Christodoulou E; German Cancer Research Center (DKFZ) Heidelberg, Division of Intelligent Medical Systems, Heidelberg, Germany., Snell KIE; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom., Sadatsafavi M; Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada., Collins GS; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom., Riley RD; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom.
Source: Journal of clinical epidemiology [J Clin Epidemiol] 2026 Mar; Vol. 191, pp. 112117. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 8801383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5921 (Electronic) Linking ISSN: 08954356 NLM ISO Abbreviation: J Clin Epidemiol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Legha+A%22">Legha A</searchLink>; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom. Electronic address: a.legha@bham.ac.uk.<br /><searchLink fieldCode="AU" term="%22Ensor+J%22">Ensor J</searchLink>; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Whittle+R%22">Whittle R</searchLink>; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Archer+L%22">Archer L</searchLink>; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom; Institute of Data and AI, University of Birmingham, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Van+Calster+B%22">Van Calster B</searchLink>; Leuven Unit for Health Technology Assessment Research (LUHTAR), KU Leuven, Leuven, Belgium; Department of Development and Regeneration, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Christodoulou+E%22">Christodoulou E</searchLink>; German Cancer Research Center (DKFZ) Heidelberg, Division of Intelligent Medical Systems, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Snell+KIE%22">Snell KIE</searchLink>; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sadatsafavi+M%22">Sadatsafavi M</searchLink>; Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Collins+GS%22">Collins GS</searchLink>; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Riley+RD%22">Riley RD</searchLink>; Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom.
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  Data: <searchLink fieldCode="JN" term="%228801383%22">Journal of clinical epidemiology</searchLink> [J Clin Epidemiol] 2026 Mar; Vol. 191, pp. 112117. <i>Date of Electronic Publication: </i>2025 Dec 19.
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              Text: 2026 Mar
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