Discovery of novel progesterone-heterocyclic conjugates and their encapsulated polymeric nanoparticles as potential CDK8 inhibitors: lung cytotoxicity evaluation, gene expression, and molecular docking.
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| Title: | Discovery of novel progesterone-heterocyclic conjugates and their encapsulated polymeric nanoparticles as potential CDK8 inhibitors: lung cytotoxicity evaluation, gene expression, and molecular docking. |
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| Authors: | Omar YY; Postgraduate program in Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Cairo Egypt.; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com., Elmasry GF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Cairo Egypt ghada.elmasry@pharma.cu.edu.eg., El-Kady DS; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com., Abd-Rabou AA; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com., El-Moghazy SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Cairo Egypt ghada.elmasry@pharma.cu.edu.eg., Awadallah FM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Cairo Egypt ghada.elmasry@pharma.cu.edu.eg., Elmegeed GA; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com., Elsayed GH; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com.; Stem Cell Lab, Centre of Excellence for Advanced Sciences, National Research Centre Cairo Egypt. |
| Source: | RSC medicinal chemistry [RSC Med Chem] 2025 Dec 18. Date of Electronic Publication: 2025 Dec 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41424683 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Discovery of novel progesterone-heterocyclic conjugates and their encapsulated polymeric nanoparticles as potential CDK8 inhibitors: lung cytotoxicity evaluation, gene expression, and molecular docking. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Omar+YY%22">Omar YY</searchLink>; Postgraduate program in Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Cairo Egypt.; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Elmasry+GF%22">Elmasry GF</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Cairo Egypt ghada.elmasry@pharma.cu.edu.eg.<br /><searchLink fieldCode="AU" term="%22El-Kady+DS%22">El-Kady DS</searchLink>; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Abd-Rabou+AA%22">Abd-Rabou AA</searchLink>; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com.<br /><searchLink fieldCode="AU" term="%22El-Moghazy+SM%22">El-Moghazy SM</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Cairo Egypt ghada.elmasry@pharma.cu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Awadallah+FM%22">Awadallah FM</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Cairo Egypt ghada.elmasry@pharma.cu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Elmegeed+GA%22">Elmegeed GA</searchLink>; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Elsayed+GH%22">Elsayed GH</searchLink>; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com.; Stem Cell Lab, Centre of Excellence for Advanced Sciences, National Research Centre Cairo Egypt. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101759460%22">RSC medicinal chemistry</searchLink> [RSC Med Chem] 2025 Dec 18. <i>Date of Electronic Publication: </i>2025 Dec 18. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Royal+Society+of+Chemistry%22">Royal Society of Chemistry </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101759460 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2632-8682 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226328682%22">26328682 </searchLink><i>NLM ISO Abbreviation: </i>RSC Med Chem |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41424683 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1039/d5md00794a Languages: – Code: eng Text: English Titles: – TitleFull: Discovery of novel progesterone-heterocyclic conjugates and their encapsulated polymeric nanoparticles as potential CDK8 inhibitors: lung cytotoxicity evaluation, gene expression, and molecular docking. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Omar YY – PersonEntity: Name: NameFull: Elmasry GF – PersonEntity: Name: NameFull: El-Kady DS – PersonEntity: Name: NameFull: Abd-Rabou AA – PersonEntity: Name: NameFull: El-Moghazy SM – PersonEntity: Name: NameFull: Awadallah FM – PersonEntity: Name: NameFull: Elmegeed GA – PersonEntity: Name: NameFull: Elsayed GH IsPartOfRelationships: – BibEntity: Dates: – D: 18 M: 12 Text: 2025 Dec 18 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2632-8682 Titles: – TitleFull: RSC medicinal chemistry Type: main |
| ResultId | 1 |
