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New coumarin-chalcone-triazole hybrids as promising anti-diabetic agents: from molecular design to in vivo validation.

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Title: New coumarin-chalcone-triazole hybrids as promising anti-diabetic agents: from molecular design to in vivo validation.
Authors: Peytam F; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences Tehran Iran.; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences Tehran Iran., Norouzbahari M; Faculty of Pharmacy, Final International University Kyrenia via Mersin 10 Turkey TRNC Catalkoy Turkey., Akbari M; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences Tehran Iran., Gülcan HO; Eastern Mediterranean University, Faculty of Pharmacy TRNC, via Mersin 10 Turkey Famagusta Cyprus., Moradi M; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences Tehran Iran., Mojtabavi S; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences Tehran Iran., Faramarzi MA; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences Tehran Iran., Ghasemi F; Department of Bioinformatics and Systems Biology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences Isfahan Iran., Torabi M; Department of Bioinformatics and Systems Biology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences Isfahan Iran., Tehrani MB; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences Tehran Iran., Sheibani V; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences Kerman Iran., Firoozpour L; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences Tehran Iran.; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences Tehran Iran., Foroumadi A; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences Tehran Iran.; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences Tehran Iran.
Source: RSC advances [RSC Adv] 2025 Dec 19; Vol. 15 (59), pp. 51136-51161. Date of Electronic Publication: 2025 Dec 19 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE
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  Data: New coumarin-chalcone-triazole hybrids as promising anti-diabetic agents: from molecular design to in vivo validation.
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  Data: <searchLink fieldCode="AU" term="%22Peytam+F%22">Peytam F</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences Tehran Iran.; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences Tehran Iran.<br /><searchLink fieldCode="AU" term="%22Norouzbahari+M%22">Norouzbahari M</searchLink>; Faculty of Pharmacy, Final International University Kyrenia via Mersin 10 Turkey TRNC Catalkoy Turkey.<br /><searchLink fieldCode="AU" term="%22Akbari+M%22">Akbari M</searchLink>; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences Tehran Iran.<br /><searchLink fieldCode="AU" term="%22Gülcan+HO%22">Gülcan HO</searchLink>; Eastern Mediterranean University, Faculty of Pharmacy TRNC, via Mersin 10 Turkey Famagusta Cyprus.<br /><searchLink fieldCode="AU" term="%22Moradi+M%22">Moradi M</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences Tehran Iran.<br /><searchLink fieldCode="AU" term="%22Mojtabavi+S%22">Mojtabavi S</searchLink>; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences Tehran Iran.<br /><searchLink fieldCode="AU" term="%22Faramarzi+MA%22">Faramarzi MA</searchLink>; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences Tehran Iran.<br /><searchLink fieldCode="AU" term="%22Ghasemi+F%22">Ghasemi F</searchLink>; Department of Bioinformatics and Systems Biology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences Isfahan Iran.<br /><searchLink fieldCode="AU" term="%22Torabi+M%22">Torabi M</searchLink>; Department of Bioinformatics and Systems Biology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences Isfahan Iran.<br /><searchLink fieldCode="AU" term="%22Tehrani+MB%22">Tehrani MB</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences Tehran Iran.<br /><searchLink fieldCode="AU" term="%22Sheibani+V%22">Sheibani V</searchLink>; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences Kerman Iran.<br /><searchLink fieldCode="AU" term="%22Firoozpour+L%22">Firoozpour L</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences Tehran Iran.; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences Tehran Iran.<br /><searchLink fieldCode="AU" term="%22Foroumadi+A%22">Foroumadi A</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences Tehran Iran.; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences Tehran Iran.
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              Text: 2025 Dec 19
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