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Reframing early-stage symptomatic knee osteoarthritis (EsSKOA): A strategic lens for trial design.

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Title: Reframing early-stage symptomatic knee osteoarthritis (EsSKOA): A strategic lens for trial design.
Authors: Mahmoudian A; Department of Movement Sciences and Health, University of West Florida, FL, USA; Department of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden. Electronic address: armaghan.mahmoudian@gmail.com., King LK; Department of Medicine, University of Toronto, Toronto, ON, Canada., Liew JW; Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Wang Q; Department of General Practice, Erasmus MC University Medical Center Rotterdam, the Netherlands., Berenbaum F; Sorbonne University INSERM, Department of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, France., Das S; Department of Rheumatology, Era's University, Lucknow, India., Ding C; Clinical Research Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China; Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia., Emery CA; Sport Injury Prevention Research Centre, Faculty of Kinesiology and Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Filbay SR; Centre for Health Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Melbourne, Australia., Hochberg MC; Department of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA., Ishijima M; Department of Orthopedics, Faculty of Medicine, Juntendo University, Tokyo, Japan., Kloppenburg M; Department of Rheumatology and Department of Clinical Epidemiology, Leiden University Medical Center, the Netherlands., Lane NE; Department of Medicine, UC Davis Health, Sacramento, CA, USA., Losina E; Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, USA; Harvard Medical School, Boston, USA., Mobasheri A; Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Department of Joint Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; World Health Organization Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Université de Liège, Liège, Belgium., Thomas Appleton C; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada; Department of Medicine, The University of Western Ontario, London, ON, Canada; Western Bone and Joint Institute, London, ON, Canada., Englund M; Department of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden., Stefan Lohmander L; Department of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden., Runhaar J; Department of General Practice, Erasmus MC University Medical Center Rotterdam, the Netherlands., Turkiewicz A; Department of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden., Hawker GA; Department of Medicine, University of Toronto, Toronto, ON, Canada., Neogi T; Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Haugen IK; Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway.
Corporate Authors: OARSI Early-stage Symptomatic Knee Osteoarthritis Initiative
Source: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2026 May; Vol. 34 (5), pp. 647-651. Date of Electronic Publication: 2025 Dec 20.
Publication Type: Editorial
Journal Info: Publisher: W.B. Saunders For The Osteoarthritis Research Society Country of Publication: England NLM ID: 9305697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-9653 (Electronic) Linking ISSN: 10634584 NLM ISO Abbreviation: Osteoarthritis Cartilage Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: Reframing early-stage symptomatic knee osteoarthritis (EsSKOA): A strategic lens for trial design.
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  Data: <searchLink fieldCode="AU" term="%22Mahmoudian+A%22">Mahmoudian A</searchLink>; Department of Movement Sciences and Health, University of West Florida, FL, USA; Department of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden. Electronic address: armaghan.mahmoudian@gmail.com.<br /><searchLink fieldCode="AU" term="%22King+LK%22">King LK</searchLink>; Department of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Liew+JW%22">Liew JW</searchLink>; Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of General Practice, Erasmus MC University Medical Center Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Berenbaum+F%22">Berenbaum F</searchLink>; Sorbonne University INSERM, Department of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Das+S%22">Das S</searchLink>; Department of Rheumatology, Era's University, Lucknow, India.<br /><searchLink fieldCode="AU" term="%22Ding+C%22">Ding C</searchLink>; Clinical Research Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China; Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.<br /><searchLink fieldCode="AU" term="%22Emery+CA%22">Emery CA</searchLink>; Sport Injury Prevention Research Centre, Faculty of Kinesiology and Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Filbay+SR%22">Filbay SR</searchLink>; Centre for Health Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Hochberg+MC%22">Hochberg MC</searchLink>; Department of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ishijima+M%22">Ishijima M</searchLink>; Department of Orthopedics, Faculty of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kloppenburg+M%22">Kloppenburg M</searchLink>; Department of Rheumatology and Department of Clinical Epidemiology, Leiden University Medical Center, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lane+NE%22">Lane NE</searchLink>; Department of Medicine, UC Davis Health, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Losina+E%22">Losina E</searchLink>; Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, USA; Harvard Medical School, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Mobasheri+A%22">Mobasheri A</searchLink>; Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Department of Joint Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; World Health Organization Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Université de Liège, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Thomas+Appleton+C%22">Thomas Appleton C</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada; Department of Medicine, The University of Western Ontario, London, ON, Canada; Western Bone and Joint Institute, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Englund+M%22">Englund M</searchLink>; Department of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Stefan+Lohmander+L%22">Stefan Lohmander L</searchLink>; Department of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Runhaar+J%22">Runhaar J</searchLink>; Department of General Practice, Erasmus MC University Medical Center Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Turkiewicz+A%22">Turkiewicz A</searchLink>; Department of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Hawker+GA%22">Hawker GA</searchLink>; Department of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Neogi+T%22">Neogi T</searchLink>; Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Haugen+IK%22">Haugen IK</searchLink>; Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway.
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  Data: <searchLink fieldCode="JN" term="%229305697%22">Osteoarthritis and cartilage</searchLink> [Osteoarthritis Cartilage] 2026 May; Vol. 34 (5), pp. 647-651. <i>Date of Electronic Publication: </i>2025 Dec 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22W%2EB%2E+Saunders+For+The+Osteoarthritis+Research+Society%22">W.B. Saunders For The Osteoarthritis Research Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9305697 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-9653 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210634584%22">10634584 </searchLink><i>NLM ISO Abbreviation: </i>Osteoarthritis Cartilage <i>Subsets: </i>MEDLINE; In Process
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