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Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk.

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Title: Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk.
Authors: Wang Y; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; ReVacc, Inc., Cambridge, MA, USA., Galkin A; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Shang X; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Marin A; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA., Jin S; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Ye TJ; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Bale S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Chiang CI; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA., Chowdhury A; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA., Chenine AL; Integrated BioTherapeutics, Inc., Rockville, MD, USA., Turonis A; Integrated BioTherapeutics, Inc., Rockville, MD, USA., Greenhouse J; BIOQUAL, Inc., Rockville, MD, USA., Stone R; BIOQUAL, Inc., Rockville, MD, USA., Wear J; BIOQUAL, Inc., Rockville, MD, USA., Kar S; BIOQUAL, Inc., Rockville, MD, USA., Andersen H; BIOQUAL, Inc., Rockville, MD, USA., Huang YS; Biosecurity Research Institute and Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA., Vanlandingham DL; Biosecurity Research Institute and Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA., Higgs S; Biosecurity Research Institute and Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA., Lapidus RG; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Fuerst T; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA., Weber DJ; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Center for Biomolecular Therapeutics, Rockville, MD, USA.; Center for Biomolecular Therapeutic, Baltimore, MD, USA., Wyatt RT; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Iffland C; OmniAb, Inc., Emeryville, CA, USA., Pierson TC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA., Andrianov AK; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA., Pozharski E; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA. epozhars@umd.edu.; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA. epozhars@umd.edu.; Center for Biomolecular Therapeutics, Rockville, MD, USA. epozhars@umd.edu.; Center for Biomolecular Therapeutic, Baltimore, MD, USA. epozhars@umd.edu., Li Y; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA. yuxingli@umd.edu.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA. yuxingli@umd.edu.; Center for Biomolecular Therapeutics, Rockville, MD, USA. yuxingli@umd.edu.; Center for Biomolecular Therapeutic, Baltimore, MD, USA. yuxingli@umd.edu.
Source: Nature communications [Nat Commun] 2025 Dec 22; Vol. 16 (1), pp. 11558. Date of Electronic Publication: 2025 Dec 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk.
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  Data: <searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; ReVacc, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Galkin+A%22">Galkin A</searchLink>; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Shang+X%22">Shang X</searchLink>; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Marin+A%22">Marin A</searchLink>; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Jin+S%22">Jin S</searchLink>; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ye+TJ%22">Ye TJ</searchLink>; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bale+S%22">Bale S</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chiang+CI%22">Chiang CI</searchLink>; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Chowdhury+A%22">Chowdhury A</searchLink>; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Chenine+AL%22">Chenine AL</searchLink>; Integrated BioTherapeutics, Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Turonis+A%22">Turonis A</searchLink>; Integrated BioTherapeutics, Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Greenhouse+J%22">Greenhouse J</searchLink>; BIOQUAL, Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Stone+R%22">Stone R</searchLink>; BIOQUAL, Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wear+J%22">Wear J</searchLink>; BIOQUAL, Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kar+S%22">Kar S</searchLink>; BIOQUAL, Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Andersen+H%22">Andersen H</searchLink>; BIOQUAL, Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Huang+YS%22">Huang YS</searchLink>; Biosecurity Research Institute and Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.<br /><searchLink fieldCode="AU" term="%22Vanlandingham+DL%22">Vanlandingham DL</searchLink>; Biosecurity Research Institute and Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.<br /><searchLink fieldCode="AU" term="%22Higgs+S%22">Higgs S</searchLink>; Biosecurity Research Institute and Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.<br /><searchLink fieldCode="AU" term="%22Lapidus+RG%22">Lapidus RG</searchLink>; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Fuerst+T%22">Fuerst T</searchLink>; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.<br /><searchLink fieldCode="AU" term="%22Weber+DJ%22">Weber DJ</searchLink>; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Center for Biomolecular Therapeutics, Rockville, MD, USA.; Center for Biomolecular Therapeutic, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wyatt+RT%22">Wyatt RT</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Iffland+C%22">Iffland C</searchLink>; OmniAb, Inc., Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pierson+TC%22">Pierson TC</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Andrianov+AK%22">Andrianov AK</searchLink>; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Pozharski+E%22">Pozharski E</searchLink>; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA. epozhars@umd.edu.; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA. epozhars@umd.edu.; Center for Biomolecular Therapeutics, Rockville, MD, USA. epozhars@umd.edu.; Center for Biomolecular Therapeutic, Baltimore, MD, USA. epozhars@umd.edu.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA. yuxingli@umd.edu.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA. yuxingli@umd.edu.; Center for Biomolecular Therapeutics, Rockville, MD, USA. yuxingli@umd.edu.; Center for Biomolecular Therapeutic, Baltimore, MD, USA. yuxingli@umd.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Dec 22; Vol. 16 (1), pp. 11558. <i>Date of Electronic Publication: </i>2025 Dec 22.
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