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Basonuclin-2 promotes fracture repair through NuRD-dependent chromatin remodeling in periosteal stem cells.

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Title: Basonuclin-2 promotes fracture repair through NuRD-dependent chromatin remodeling in periosteal stem cells.
Authors: Zhang Z; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China.; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Zhang L; School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China., Jiang B; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China.; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Chen S; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China., Xing W; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China., Wang P; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Lou L; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Tang C; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China., Hu X; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Suo J; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Zhou BO; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Zou W; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China. zouwg94@sibcb.ac.cn.; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. zouwg94@sibcb.ac.cn., Wang L; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China. wanglijun2014@sibcb.ac.cn.
Source: The EMBO journal [EMBO J] 2026 Feb; Vol. 45 (4), pp. 1060-1076. Date of Electronic Publication: 2025 Dec 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: Basonuclin-2 promotes fracture repair through NuRD-dependent chromatin remodeling in periosteal stem cells.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China.; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Jiang+B%22">Jiang B</searchLink>; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China.; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China.<br /><searchLink fieldCode="AU" term="%22Xing+W%22">Xing W</searchLink>; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China.<br /><searchLink fieldCode="AU" term="%22Wang+P%22">Wang P</searchLink>; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Lou+L%22">Lou L</searchLink>; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Tang+C%22">Tang C</searchLink>; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Suo+J%22">Suo J</searchLink>; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Zhou+BO%22">Zhou BO</searchLink>; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Zou+W%22">Zou W</searchLink>; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China. zouwg94@sibcb.ac.cn.; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. zouwg94@sibcb.ac.cn.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China. wanglijun2014@sibcb.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 Feb; Vol. 45 (4), pp. 1060-1076. <i>Date of Electronic Publication: </i>2025 Dec 22.
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