Systematic review and meta-analysis of humoral immunity proteins and mortality in sepsis.

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Title: Systematic review and meta-analysis of humoral immunity proteins and mortality in sepsis.
Authors: Villa A; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK., Dewar F; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK., Pisciotta W; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.; Department of Anesthesia and Intensive Care, IRCCS-ISMETT, Palermo, Italy., Rai A; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK., Kerneis S; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK., Batum G; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK., McDonnell T; Institute of Inflammation and Repair, University College London, London, UK., Scully M; Department of Haematology, UCLH and Haematology Programme-NIHR UCLH/UCL BRC, London, UK., McHugh TD; Centre for Clinical Microbiology, Division of Infection and Immunity, University College London, London, UK., Hilpert K; Institute for Infection and Immunity, St George's, University of London, London, UK., Gilroy D; Centre for Clinical Pharmacology, University College London, London, UK., de Nooijer A; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Netea MG; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Hedetoft M; Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Bermejo-Martin JF; Universidad de Salamanca & Instituto de Investigación Biomédica de Salamanca (IBSAL) & CIBERES, Instituto de Salud Carlos III, Madrid, Spain., Akatsuka M; Department of Biochemistry, Department of Intensive Care Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan., Heinz CC; Department of Clinical Research and Development, Biotest, Dreieich, AG, Germany., Venet F; CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, École Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, F-69007, France.; Laboratoire d'Immunologie, Hôpital E. Herriot, Hospices Civils de Lyon, Lyon, France., Monneret G; Laboratoire d'Immunologie, Hôpital E. Herriot, Hospices Civils de Lyon, Lyon, France., Meessen J; Department of Acute, Brain and Cardiovascular Injury, Institute for Pharmacological Research Mario Negri IRCCS, Milan, Italy., Cheng TH; Department of Anesthesiology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA., Zhang M; Department of Anesthesiology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA., Caironi P; Department of Acute, Brain and Cardiovascular Injury, Institute for Pharmacological Research Mario Negri IRCCS, Milan, Italy.; Department of Oncology, University of Turin, Turin, Italy., Giamarellos-Bourboulis EJ; Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece., de la Torre Terrón MC; Department of Intensive Care Medicine, Hospital Universitari de Mataró, Consorci Sanitari del Maresme, Mataró, Spain., Ebelt H; Department of Internal Medicine III, University Hospital Halle (Saale), Catholic Hospital St. Johann Nepomuk, Halle, Erfurt, Germany., Rademaker E; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, Netherlands., Bodelsson M; Department of Clinical Sciences, Lund University, Lund, Sweden., Tverring J; Department of Clinical Sciences, Lund University, Lund, Sweden., Mi Y; Centre for Human Genetics, University of Oxford, Oxford, UK., Knight JC; Centre for Human Genetics, University of Oxford, Oxford, UK., Lindsey ML; Department of Applied Education, Department of Biomedical Sciences, Meharry Medical College, Nashville, TN, USA.; Research Service, Nashville VA Medical Center, Nashville, TN, USA., Langley RJ; Department of Pharmacology, Whiddon College of Medicine, University of South Alabama, Mobile, AL, USA., Kingsmore SF; Rady Children's Institute for Genomic Medicine, Rady Children's Hospital, San Diego, CA, USA., Brealey D; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK., Singer M; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK., Arulkumaran N; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK. n.arulkumaran@ucl.ac.uk.
Source: Critical care (London, England) [Crit Care] 2025 Dec 22; Vol. 30 (1), pp. 41. Date of Electronic Publication: 2025 Dec 22.
Publication Type: Journal Article; Meta-Analysis; Systematic Review
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Villa+A%22">Villa A</searchLink>; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Dewar+F%22">Dewar F</searchLink>; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Pisciotta+W%22">Pisciotta W</searchLink>; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.; Department of Anesthesia and Intensive Care, IRCCS-ISMETT, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Rai+A%22">Rai A</searchLink>; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kerneis+S%22">Kerneis S</searchLink>; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Batum+G%22">Batum G</searchLink>; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22McDonnell+T%22">McDonnell T</searchLink>; Institute of Inflammation and Repair, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Scully+M%22">Scully M</searchLink>; Department of Haematology, UCLH and Haematology Programme-NIHR UCLH/UCL BRC, London, UK.<br /><searchLink fieldCode="AU" term="%22McHugh+TD%22">McHugh TD</searchLink>; Centre for Clinical Microbiology, Division of Infection and Immunity, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Hilpert+K%22">Hilpert K</searchLink>; Institute for Infection and Immunity, St George's, University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Gilroy+D%22">Gilroy D</searchLink>; Centre for Clinical Pharmacology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22de+Nooijer+A%22">de Nooijer A</searchLink>; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Netea+MG%22">Netea MG</searchLink>; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Hedetoft+M%22">Hedetoft M</searchLink>; Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bermejo-Martin+JF%22">Bermejo-Martin JF</searchLink>; Universidad de Salamanca & Instituto de Investigación Biomédica de Salamanca (IBSAL) & CIBERES, Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Akatsuka+M%22">Akatsuka M</searchLink>; Department of Biochemistry, Department of Intensive Care Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Heinz+CC%22">Heinz CC</searchLink>; Department of Clinical Research and Development, Biotest, Dreieich, AG, Germany.<br /><searchLink fieldCode="AU" term="%22Venet+F%22">Venet F</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, École Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, F-69007, France.; Laboratoire d'Immunologie, Hôpital E. Herriot, Hospices Civils de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Monneret+G%22">Monneret G</searchLink>; Laboratoire d'Immunologie, Hôpital E. Herriot, Hospices Civils de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Meessen+J%22">Meessen J</searchLink>; Department of Acute, Brain and Cardiovascular Injury, Institute for Pharmacological Research Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Cheng+TH%22">Cheng TH</searchLink>; Department of Anesthesiology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Department of Anesthesiology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.<br /><searchLink fieldCode="AU" term="%22Caironi+P%22">Caironi P</searchLink>; Department of Acute, Brain and Cardiovascular Injury, Institute for Pharmacological Research Mario Negri IRCCS, Milan, Italy.; Department of Oncology, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Giamarellos-Bourboulis+EJ%22">Giamarellos-Bourboulis EJ</searchLink>; Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22de+la+Torre+Terrón+MC%22">de la Torre Terrón MC</searchLink>; Department of Intensive Care Medicine, Hospital Universitari de Mataró, Consorci Sanitari del Maresme, Mataró, Spain.<br /><searchLink fieldCode="AU" term="%22Ebelt+H%22">Ebelt H</searchLink>; Department of Internal Medicine III, University Hospital Halle (Saale), Catholic Hospital St. Johann Nepomuk, Halle, Erfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Rademaker+E%22">Rademaker E</searchLink>; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Bodelsson+M%22">Bodelsson M</searchLink>; Department of Clinical Sciences, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Tverring+J%22">Tverring J</searchLink>; Department of Clinical Sciences, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Mi+Y%22">Mi Y</searchLink>; Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Knight+JC%22">Knight JC</searchLink>; Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lindsey+ML%22">Lindsey ML</searchLink>; Department of Applied Education, Department of Biomedical Sciences, Meharry Medical College, Nashville, TN, USA.; Research Service, Nashville VA Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Langley+RJ%22">Langley RJ</searchLink>; Department of Pharmacology, Whiddon College of Medicine, University of South Alabama, Mobile, AL, USA.<br /><searchLink fieldCode="AU" term="%22Kingsmore+SF%22">Kingsmore SF</searchLink>; Rady Children's Institute for Genomic Medicine, Rady Children's Hospital, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Brealey+D%22">Brealey D</searchLink>; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Singer+M%22">Singer M</searchLink>; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Arulkumaran+N%22">Arulkumaran N</searchLink>; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK. n.arulkumaran@ucl.ac.uk.
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